Tìm theo
Benzocaine
Các tên gọi khác (11 ) :
  • 4-aminobenzoic acid ethyl ester
  • Amben ethyl ester
  • Benzocaina
  • Benzocaine
  • Benzocainum
  • Ethyl Aminobenzoate
  • Ethyl p-Aminobenzoate
  • Ethyl p-Aminophenylcarboxylate
  • p-(Ethoxycarbonyl)aniline
  • p-Carbethoxyaniline
  • p-Ethoxycarboxylic Aniline
Thuốc gây mê
Thuốc Gốc
Small Molecule
CAS: 94-09-7
ATC: C05AD03, D04AB04, N01BA05, R02AD01
ĐG : Advanced Pharmaceutical Services Inc.
CTHH: C9H11NO2
PTK: 165.1891
A surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C9H11NO2
Phân tử khối
165.1891
Monoisotopic mass
165.078978601
InChI
InChI=1S/C9H11NO2/c1-2-12-9(11)7-3-5-8(10)6-4-7/h3-6H,2,10H2,1H3
InChI Key
InChIKey=BLFLLBZGZJTVJG-UHFFFAOYSA-N
IUPAC Name
ethyl 4-aminobenzoate
Traditional IUPAC Name
benzocaine
SMILES
CCOC(=O)C1=CC=C(N)C=C1
Độ tan chảy
92 °C
Độ sôi
310 °C
Độ hòa tan
1310 mg/L (at 30 °C)
logP
1.86
logS
-1.8
pKa (Strongest Basic)
2.78
PSA
52.32 Å2
Refractivity
47.53 m3·mol-1
Polarizability
17.46 Å3
Rotatable Bond Count
3
H Bond Acceptor Count
2
H Bond Donor Count
1
Physiological Charge
0
Number of Rings
1
Bioavailability
1
Rule of Five
true
Ghose Filter
true
pKa
2.51 (at 25 °C)
Dược Lực Học : Benzocaine is a local anesthetic commonly used as a topical pain reliever. It is the active ingredient in many over-the-counter analgesic ointments. It is also indicated for general use as a lubricant and topical anesthetic on intratracheal catheters and pharyngeal and nasal airways to obtund the pharyngeal and tracheal reflexes; on nasogastric and endoscopic tubes; urinary catheters; laryngoscopes; proctoscopes; sigmoidoscopes and vaginal specula.
Cơ Chế Tác Dụng : A surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings. [PubChem] Benzocaine binds to sodium channels and reversibly stabilizes the neuronal membrane which decreases its permeability to sodium ions. Depolarization of the neuronal membrane is inhibited thereby blocking the initiation and conduction of nerve impulses.
Độc Tính : LD50=3040 mg/kg (rat, oral)
Chỉ Định : For general use as a lubricant and topical anesthetic on esophagus, larynx, mouth, nasal cavity, rectum, respiratory tract or trachea, urinary tract, vagina. It is also used to suppress gag reflex.
Liều Lượng & Cách Dùng : Aerosol - Buccal
Aerosol - Dental
Gel - Dental
Gel - Oral
Gel - Topical
Liquid - Oral
Liquid - Topical
Ointment - Topical
Paste - Dental
Paste - Oral
Swab - Oral
Swab - Topical
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Americaine
  • Công ty :
    Sản phẩm biệt dược : Anacaine
  • Công ty :
    Sản phẩm biệt dược : Anaesthesin
  • Công ty :
    Sản phẩm biệt dược : Anbesol Baby
  • Công ty :
    Sản phẩm biệt dược : Dermoplast
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01086
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=2337
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46508891
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C07527
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00552
ChemSpider
http://www.chemspider.com/Chemical-Structure.13854242.html
PharmGKB
http://www.pharmgkb.org/drug/PA448576
Wikipedia
http://en.wikipedia.org/wiki/Benzocaine
RxList
http://www.rxlist.com/cgi/generic3/americaine.htm
Drugs.com
http://www.drugs.com/cdi/benzocaine-drops.html
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