Tìm theo
Bentiromide
Các tên gọi khác (5 ) :
  • Bentiromide
  • Bentiromido
  • Bentiromidum
  • BTPABA
  • PFT
indicators and reagents, diagnostic agents
Thuốc Gốc
Small Molecule
CAS: 37106-97-1
ATC: V04CK03
CTHH: C23H20N2O5
PTK: 404.4153
Bentiromide is a peptide used as a screening test for exocrine pancreatic insufficiency and to monitor the adequacy of supplemental pancreatic therapy. It is given by mouth as a noninvasive test. The amount of 4-aminobenzoic acid and its metabolites excreted in the urine is taken as a measure of the chymotrypsin-secreting activity of the pancreas. Headache and gastrointestinal disturbances have been reported in patients taking bentiromide. Bentiromide is not available in the U.S. or Canada (It was withdrawn in the US in October 1996).
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C23H20N2O5
Phân tử khối
404.4153
Monoisotopic mass
404.13722176
InChI
InChI=1S/C23H20N2O5/c26-19-12-6-15(7-13-19)14-20(25-21(27)16-4-2-1-3-5-16)22(28)24-18-10-8-17(9-11-18)23(29)30/h1-13,20,26H,14H2,(H,24,28)(H,25,27)(H,29,30)/t20-/m0/s1
InChI Key
InChIKey=SPPTWHFVYKCNNK-FQEVSTJZSA-N
IUPAC Name
4-[(2S)-3-(4-hydroxyphenyl)-2-(phenylformamido)propanamido]benzoic acid
Traditional IUPAC Name
PFT
SMILES
OC(=O)C1=CC=C(NC(=O)[C@H](CC2=CC=C(O)C=C2)NC(=O)C2=CC=CC=C2)C=C1
Độ tan chảy
240-242
Độ hòa tan
4.12e-03 g/l
logP
3.3
logS
-5
pKa (strongest acidic)
4.16
pKa (Strongest Basic)
-1.3
PSA
115.73 Å2
Refractivity
112.75 m3·mol-1
Polarizability
42.16 Å3
Rotatable Bond Count
7
H Bond Acceptor Count
5
H Bond Donor Count
4
Physiological Charge
-1
Number of Rings
3
Bioavailability
1
Rule of Five
true
Ghose Filter
true
MDDR-Like Rule
true
Dược Lực Học : Bentiromide is a peptide used as a screening test for exocrine pancreatic insufficiency and to monitor the adequacy of supplemental pancreatic therapy. It is given by mouth as a noninvasive test. The amount of p-aminobenzoic acid and its metabolites excreted in the urine is taken as a measure of the chymotrypsin-secreting activity of the pancreas. Headache and gastrointestinal disturbances have been reported in patients taking bentiromide. Bentiromide is not available in the U.S. or Canada.
Cơ Chế Tác Dụng : Bentiromide is a peptide used as a screening test for exocrine pancreatic insufficiency and to monitor the adequacy of supplemental pancreatic therapy. It is given by mouth as a noninvasive test. The amount of 4-aminobenzoic acid and its metabolites excreted in the urine is taken as a measure of the chymotrypsin-secreting activity of the pancreas. Headache and gastrointestinal disturbances have been reported in patients taking bentiromide. Bentiromide is not available in the U.S. or Canada (It was withdrawn in the US in October 1996). Bentiromide is a peptide that is broken down in the pancreas by chymotrypsin. By determining the output of unchanged bentiromide in the urine following oral administration, it is possible to determine the sufficiency of pancreatic activity.
Dược Động Học :

▧ Metabolism :
Primarily hepatic. Enzymatic activity capable of hydrolyzing bentiromide has also been found in normal small intestine.
Độc Tính : Symptoms of overdose include shortness of breath and troubled breathing.
Chỉ Định : Used as a screening test for exocrine pancreatic insufficiency and to monitor the adequacy of supplemental pancreatic therapy.
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty : Sannova
    Sản phẩm biệt dược : PFD
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00522
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D01346
PharmGKB
http://www.pharmgkb.org/drug/PA164750572
Wikipedia
http://en.wikipedia.org/wiki/Bentiromide
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