Tìm theo
Becaplermin
Các tên gọi khác (5 ) :
  • c-sis
  • PDGF B-chain
  • PDGF-2
  • Platelet-derived growth factor B chain precursor
  • Platelet-derived growth factor beta polypeptide
angiogenesis inducing agents
Thuốc Gốc
Biotech
CAS: 165101-51-9
ATC: A01AD08, D03AX06
ĐG : Janssen-Ortho Inc. , http://www.janssen-ortho.com
CTHH: C532H892N162O153S9
PTK: 12294.4000
Becaplermin is produced by recombinant DNA technology by insertion of the gene for the B chain of platelet derived growth factor (PDGF) into the yeast, Saccharomyces cerevisiae. Becaplermin has a molecular weight of approximately 25 KD and is a homodimer composed of two identical polypeptide chains that are bound together by disulfide bonds
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C532H892N162O153S9
Phân tử khối
12294.4000
Độ kỵ nước
-0.160
Điểm đẳng điện tích
9.38
Dược Lực Học : Used for the topical treatment of skin ulcers, Regranex has a biological activity similar to that of endogenous platelet-derived growth factor, which includes promoting the chemotactic recruitment and proliferation of cells involved in wound repair and enhancing the formation of granulation tissue.
Cơ Chế Tác Dụng : Becaplermin is produced by recombinant DNA technology by insertion of the gene for the B chain of platelet derived growth factor (PDGF) into the yeast, Saccharomyces cerevisiae. Becaplermin has a molecular weight of approximately 25 KD and is a homodimer composed of two identical polypeptide chains that are bound together by disulfide bonds Binds to the beta platelet-derived growth factor (PDGF) receptor, a tyrosine kinase receptor. PDGF is known to exist as a dimer, and activates its signaling pathway by a ligand induced receptor dimerization and autophosphorylation. PDGF receptors also contain many auto-phosphorylation sites, which serve to mediate binding of SH2 sites and subsequently signal corresponding pathways. There are five different isoforms of PDGF that activate through two different receptors (alpha and beta).
Dược Động Học :
▧ Absorption :
very little systemic absorption. 15% of patients experienced complete healing within 8 weeks, while for 25% of patients, it was at 10 weeks.
Chỉ Định : For topical treatment of skin ulcers (from diabetes)
Liều Lượng & Cách Dùng : Gel - Topical
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00102
GenBank
http://www.ncbi.nlm.nih.gov/nuccore/K01401
PharmGKB
http://www.pharmgkb.org/drug/PA164749511
Wikipedia
http://en.wikipedia.org/wiki/Becaplermin
RxList
http://www.rxlist.com/cgi/generic2/becapler.htm
Drugs.com
http://www.drugs.com/cdi/becaplermin.html
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