Tìm theo
Bambuterol
Các tên gọi khác (5 ) :
  • (+-)-5-(2-(Tert-butylamino)-1-hydroxyethyl)-m-phenylene bis(dimethylcarbamate)
  • Bambuterol
  • Bambuterolum
  • Terbutaline bis(dimethylcarbamate)
  • Terbutaline bisdimethylcarbamate
Thuốc tác dụng trên đường hô hấp
Thuốc Gốc
Small Molecule
CAS: 81732-46-9
ATC: R03CC12
CTHH: C18H29N3O5
PTK: 367.44
Bambuterol is a long acting beta-adrenoceptor agonist used in the treatment of asthma. It is a prodrug of terbutaline.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C18H29N3O5
Phân tử khối
367.44
Monoisotopic mass
367.210721053
InChI
InChI=1S/C18H29N3O5/c1-18(2,3)19-11-15(22)12-8-13(25-16(23)20(4)5)10-14(9-12)26-17(24)21(6)7/h8-10,15,19,22H,11H2,1-7H3
InChI Key
InChIKey=ANZXOIAKUNOVQU-UHFFFAOYSA-N
IUPAC Name
3-[2-(tert-butylamino)-1-hydroxyethyl]-5-[(dimethylcarbamoyl)oxy]phenyl N,N-dimethylcarbamate
Traditional IUPAC Name
bambuterol
SMILES
CN(C)C(=O)OC1=CC(=CC(OC(=O)N(C)C)=C1)C(O)CNC(C)(C)C
Độ hòa tan
4.69e-01 g/l
logP
1.4
logS
-2.9
pKa (strongest acidic)
13.91
pKa (Strongest Basic)
9.52
PSA
91.34 Å2
Refractivity
98.28 m3·mol-1
Polarizability
40.74 Å3
Rotatable Bond Count
8
H Bond Acceptor Count
4
H Bond Donor Count
2
Physiological Charge
1
Number of Rings
1
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Bambuterol is a long acting beta2-adrenoceptor agonist used in the treatment of asthma. It is a prodrug of terbutaline. Bambuterol causes smooth muscle relaxation, resulting in dilation of bronchial passages.
Cơ Chế Tác Dụng : Bambuterol is a long acting beta-adrenoceptor agonist used in the treatment of asthma. It is a prodrug of terbutaline. The pharmacologic effects of bambuterol are at least in part attributable to stimulation through beta-adrenergic receptors (beta 2 receptors) of intracellular adenyl cyclase, the enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic AMP. Increased cyclic AMP levels are associated with relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from cells, especially from mast cells.
Dược Động Học :
▧ Absorption :
Bioavailability is 20% following oral administration.
▧ Metabolism :
Hepatic, extensive. Further metabolized to terbutaline by plasma cholinesterase.
▧ Half Life :
13 hours for bambuterol and 21 hours for the primary active metabolite terbutaline.
Chỉ Định : For the prevention and reversal of bronchospasm in patients 12 years of age and older with asthma and reversible bronchospasm associated with bronchitis and emphysema.
Tương Tác Thuốc :
  • Indacaterol Concomitant use with other inhaled, long acting beta2-adrenergic drugs may result in an overdose. Adverse cardiovascular effects and fatalities have been associated with excessive use of inhaled sympathomimetic drugs.
Liều Lượng & Cách Dùng : Tablet - Oral
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Bambec
  • Công ty :
    Sản phẩm biệt dược : Oxeol
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01408
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=54766
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46505785
ChemSpider
http://www.chemspider.com/Chemical-Structure.49466.html
PharmGKB
http://www.pharmgkb.org/drug/PA164743113
Wikipedia
http://en.wikipedia.org/wiki/Bambuterol
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