Tìm theo
Bacampicillin
Các tên gọi khác (5 ) :
  • 1-[(Ethoxycarbonyl)oxy]ethyl (2S,5R,6R)-6-{[(2R)-2-amino-2-phenylacetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
  • 1'-Ethoxycarbonyloxyethyl-(6-D-alpha-aminophenylacetamido)penicillanate
  • Bacampicilina
  • Bacampicilline
  • Bacampicillinum
penicillins
Thuốc Gốc
Small Molecule
CAS: 50972-17-3
ĐG : Pfizer Inc. , http://www.pfizer.com
CTHH: C21H27N3O7S
PTK: 465.52
Bacampicillin is a prodrug of ampicillin and is microbiologically inactive. It is absorbed following oral administration. During absorption from the gastrointestinal tract, bacampicillin is hydrolyzed by esterases present in the intestinal wall. It is microbiologically active as ampicillin, and exerts a bactericidal action through the inhibition of the biosynthesis of cell wall mucopeptides. It is used to cure infection of upper and lower respiratory tract; skin and soft tissue; urinary tract and acute uncomplicated gonococcal urethritis etc.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C21H27N3O7S
Phân tử khối
465.52
Monoisotopic mass
465.156970923
InChI
InChI=1S/C21H27N3O7S/c1-5-29-20(28)31-11(2)30-19(27)15-21(3,4)32-18-14(17(26)24(15)18)23-16(25)13(22)12-9-7-6-8-10-12/h6-11,13-15,18H,5,22H2,1-4H3,(H,23,25)/t11?,13-,14-,15+,18-/m1/s1
InChI Key
InChIKey=PFOLLRNADZZWEX-FFGRCDKISA-N
IUPAC Name
1-[(ethoxycarbonyl)oxy]ethyl (2S,5R,6R)-6-[(2R)-2-amino-2-phenylacetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
Traditional IUPAC Name
bacampicillin
SMILES
[H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)[C@H](N)C1=CC=CC=C1)C(=O)OC(C)OC(=O)OCC
Độ tan chảy
171-176
Độ hòa tan
1.23e-01 g/l
logP
1.47
logS
-3.6
pKa (strongest acidic)
11.72
pKa (Strongest Basic)
7.44
PSA
137.26 Å2
Refractivity
113.76 m3·mol-1
Polarizability
46.8 Å3
Rotatable Bond Count
10
H Bond Acceptor Count
6
H Bond Donor Count
2
Physiological Charge
1
Number of Rings
3
Bioavailability
1
Rule of Five
true
Ghose Filter
true
MDDR-Like Rule
true
Dược Lực Học : Bacampicillin is a prodrug of ampicillin and is microbiologically inactive.
Cơ Chế Tác Dụng : Bacampicillin is a prodrug of ampicillin and is microbiologically inactive. It is absorbed following oral administration. During absorption from the gastrointestinal tract, bacampicillin is hydrolyzed by esterases present in the intestinal wall. It is microbiologically active as ampicillin, and exerts a bactericidal action through the inhibition of the biosynthesis of cell wall mucopeptides. It is used to cure infection of upper and lower respiratory tract; skin and soft tissue; urinary tract and acute uncomplicated gonococcal urethritis etc. During absorption from the gastrointestinal tract, bacampicillin is hydrolyzed by esterases present in the intestinal wall. It is microbiologically active as ampicillin, and exerts a bactericidal action through the inhibition of the biosynthesis of cell wall mucopeptides.
Dược Động Học :
▧ Absorption :
Absorbed following oral administration.
Chỉ Định : For infections at the following sites: upper and lower respiratory tract; skin and soft tissue; urinary tract and acute uncomplicated gonococcal urethritis, when due to sensitive strains of the following organisms: Gram-positive: streptococci (including S. faecalis and S. pneumoniae) and nonpenicillinase-producing staphylococci; Gram-negative: H. influenzae, N. gonorrhoeae, E. coli, P. mirabilis, Salmonellae and Shigellae.
Tương Tác Thuốc :
Liều Lượng & Cách Dùng : Suspension - Oral
Tablet - Oral
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty : Upjohn
    Sản phẩm biệt dược : Ambaxin
  • Công ty : Pfizer
    Sản phẩm biệt dược : BacaciI
  • Công ty : Upjohn
    Sản phẩm biệt dược : Bamaxin
  • Công ty : AstraZeneca
    Sản phẩm biệt dược : Penglobe
  • Công ty : Pfizer
    Sản phẩm biệt dược : Spectrobid
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01602
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=441397
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46507859
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C08122
ChemSpider
http://www.chemspider.com/Chemical-Structure.390135.html
PharmGKB
http://www.pharmgkb.org/drug/PA164745461
Drugs.com
http://www.drugs.com/mtm/bacampicillin.html
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