Tìm theo
Azidocillin
Các tên gọi khác (5 ) :
  • (2S,5R,6R)-6-{[(2R)-2-azido-2-phenylacetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
  • Azidocilina
  • Azidocilline
  • Azidocillinum
  • D-(-)-(alpha-Azidobenzyl)penicillin
Thuốc trị ký sinh trùng, chống nhiễm khuẩn
Thuốc Gốc
Small Molecule
CAS: 17243-38-8
ATC: J01CE04
CTHH: C16H17N5O4S
PTK: 375.402
Azidocillin is a penicillin antibiotic similir to ampicillin.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C16H17N5O4S
Phân tử khối
375.402
Monoisotopic mass
375.100124747
InChI
InChI=1S/C16H17N5O4S/c1-16(2)11(15(24)25)21-13(23)10(14(21)26-16)18-12(22)9(19-20-17)8-6-4-3-5-7-8/h3-7,9-11,14H,1-2H3,(H,18,22)(H,24,25)/t9-,10-,11+,14-/m1/s1
InChI Key
InChIKey=ODFHGIPNGIAMDK-NJBDSQKTSA-N
IUPAC Name
(2S,5R,6R)-6-[(2R)-2-azido-2-phenylacetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Traditional IUPAC Name
azidocillin
SMILES
[H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)[C@H](N=[N+]=[N-])C1=CC=CC=C1)C(O)=O
Độ hòa tan
6.11e-01 g/l
logP
1.19
logS
-2.8
pKa (strongest acidic)
3.32
pKa (Strongest Basic)
-6.4
PSA
116.14 Å2
Refractivity
92.16 m3·mol-1
Polarizability
35.87 Å3
Rotatable Bond Count
5
H Bond Acceptor Count
6
H Bond Donor Count
2
Physiological Charge
-1
Number of Rings
3
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Cơ Chế Tác Dụng : Azidocillin is a penicillin antibiotic similir to ampicillin. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, Azidocillin inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that Azidocillin interferes with an autolysin inhibitor.
Chỉ Định : For treatment of infection (Respiratory, GI, UTI and meningitis) due to E. coli, P. mirabilis, enterococci, Shigella, S. typhosa and other Salmonella, nonpenicillinase-producing N. gononhoeae, H. influenzae, staphylococci, streptococci including streptoc
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty : Panbiotic
    Sản phẩm biệt dược : Alocillin
  • Công ty : Conba
    Sản phẩm biệt dược : Alocin
  • Công ty : Balkanpharma
    Sản phẩm biệt dược : Azlocillin
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB08795
PharmGKB
http://www.pharmgkb.org/drug/PA165958414
Wikipedia
http://en.wikipedia.org/wiki/Azidocillin
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