Tìm theo
AV411
Thuốc Gốc
Small Molecule
AV411 is an orally bioavailable, centrally acting molecule that Avigen has identified as having potential utility for the treatment of neuropathic pain and other neurological indications, including opiate withdrawal. The active pharmaceutical ingredient in AV411 is ibudilast.
Dược Lực Học : Release of factors such as substance P, chemokines such as fractalkine, and cytokines including IL-1 and TNFα play a role in amplifying afferent sensory input and causing or exacerbating painful sensations. AV411 has been found to suppress the production of pro-inflammatory cytokines (IL-1beta, TNF-alpha , IL-6), and may enhance the production of the anti-inflammatory cytokine IL-10, and upregulate release of neurotrophic factors (NGF, GDNF, NT-4).
Cơ Chế Tác Dụng : AV411 is an orally bioavailable, centrally acting molecule that Avigen has identified as having potential utility for the treatment of neuropathic pain and other neurological indications, including opiate withdrawal. The active pharmaceutical ingredient in AV411 is ibudilast. AV411 suppresses the production of pro-inflammatory cytokines (IL-1beta, TNF-alpha , IL-6), and may enhance the production of the anti-inflammatory cytokine IL-10, and upregulate release of neurotrophic factors (NGF, GDNF, NT-4).
Chỉ Định : Investigated for use/treatment in neuropathy (diabetic) and pain (acute or chronic).
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB05066
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