Tìm theo
Auranofin
Các tên gọi khác (8 ) :
  • (1-Thio-beta-D-glucopyranosato)(triethylphosphine)gold 2,3,4,6-tetraacetate
  • 2,3,4,6-Tetra-O-acetyl-1-thio-beta-D-glucopyranosato-S (triethylphosphine)gold
  • Auranofina
  • Auranofine
  • Auranofinum
  • Auroafen
  • Ridaura
  • Triethylphosphine gold
antirheumatic agents
Thuốc Gốc
Small Molecule
CAS: 34031-32-8
ATC: M01CB03
ĐG : Catalent Pharma Solutions , http://www.catalent.com
CTHH: C20H34AuO9PS
PTK: 678.484
Auranofin is a organogold compound classified by the World Health Organization as an antirheumatic agent. Auranofin appears to induce heme oxygenase 1 (HO-1) mRNA. Heme oxygenase 1 is an inducible heme-degrading enzyme with anti-inflammatory properties.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C20H34AuO9PS
Phân tử khối
678.484
Monoisotopic mass
678.132666497
InChI
InChI=1S/C14H20O9S.C6H15P.Au/c1-6(15)19-5-10-11(20-7(2)16)12(21-8(3)17)13(14(24)23-10)22-9(4)18;1-4-7(5-2)6-3;/h10-14,24H,5H2,1-4H3;4-6H2,1-3H3;/q;;+1/p-1/t10-,11-,12+,13-,14+;;/m1../s1
InChI Key
InChIKey=AUJRCFUBUPVWSZ-XTZHGVARSA-M
IUPAC Name
[(2R,3R,4S,5R,6S)-3,4,5-tris(acetyloxy)-6-{[(triethyl-$l^{5}-phosphanylidene)aurio]sulfanyl}oxan-2-yl]methyl acetate
Traditional IUPAC Name
auranofin
SMILES
CCP(CC)(CC)=[Au]S[C@@H]1O[C@H](COC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]1OC(C)=O
Độ tan chảy
110-111
Độ hòa tan
1.51e-01 g/l
logP
-1
logS
-3.6
pKa (Strongest Basic)
-4.3
PSA
114.43 Å2
Refractivity
114.89 m3·mol-1
Polarizability
50.64 Å3
Rotatable Bond Count
14
H Bond Acceptor Count
5
H Bond Donor Count
0
Physiological Charge
0
Number of Rings
1
Bioavailability
0
Dược Lực Học : Auranofin is a gold salt used in treating inflammatory arthritis. Gold salts are called second-line drugs because they are often considered when the arthritis progresses in spite of antiinflammatory drugs (NSAIDs and corticosteroids).
Cơ Chế Tác Dụng : Auranofin is a organogold compound classified by the World Health Organization as an antirheumatic agent. Auranofin appears to induce heme oxygenase 1 (HO-1) mRNA. Heme oxygenase 1 is an inducible heme-degrading enzyme with anti-inflammatory properties. Exactly how auranofin works is not well understood. It may act as an inhibitor of kappab kinase and thioredoxin reductase which would lead to a decreased immune response and decreased free radical production, respectively. In patients with inflammatory arthritis, such as adult and juvenile rheumatoid arthritis, gold salts can decrease the inflammation of the joint lining. This effect can prevent destruction of bone and cartilage.
Dược Động Học :

▧ Route of Elimination :
Approximately 60% of the absorbed gold (15% of the administered dose) from a single dose of auranofin is excreted in urine; the remainder is excreted in the feces.
Độc Tính : Oral, rat: LD50 = > 2000 mg/kg. Symptoms of overdose may include diarrhoea, vomiting, abdominal cramps, and symptoms of hypersensitivity (such as skin rash, hives, itching, and difficulty breathing).
Chỉ Định : Used in the treatment of active, progressive or destructive forms of inflammatory arthritis, such as adult rheumatoid arthritis.
Liều Lượng & Cách Dùng : Capsule - Oral
Dữ Kiện Thương Mại
Giá thị trường
  • Biệt dược thương mại : Ridaura 3 mg capsule
    Giá bán buôn : USD >5.17
    Đơn vị tính : capsule
Nhà Sản Xuất
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00995
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00237
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/65483-093-06
PharmGKB
http://www.pharmgkb.org/drug/PA448510
Wikipedia
http://en.wikipedia.org/wiki/Auranofin
PDRhealth
http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/rid1379.shtml
Drugs.com
http://www.drugs.com/cdi/auranofin.html
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