Tìm theo
Atropine
Các tên gọi khác (17 ) :
  • (+-)-Atropine
  • (+-)-Hyoscyamine
  • (+,-)-Tropyl tropate
  • (±)-atropine
  • (±)-hyoscyamine
  • (3-Endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl tropate
  • [(1S,5R)-8-Methyl-8-azabicyclo[3.2.1]oct-3-yl] 3-hydroxy-2-phenyl-propanoate
  • 8-Methyl-8-azabicyclo[3.2.1]oct-3-yl 3-hydroxy-2-phenylpropanoate
  • 8-Methyl-8-azabicyclo[3.2.1]oct-3-yl tropate
  • Atropin
  • Atropina
  • Atropine
  • Atropinum
  • dl-Hyoscyamine
  • dl-tropyltropate
  • Mydriasine
  • Tropine tropate
Thuốc đường tiêu hóa
Thuốc Gốc
Small Molecule
CAS: 51-55-8
ATC: A03BA01, A03BB02, N04AC30, S01FA01, S01FA05
ĐG : Advanced Pharmaceutical Services Inc.
CTHH: C17H23NO3
PTK: 289.3694
An alkaloid, originally from Atropa belladonna, but found in other plants, mainly solanaceae. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C17H23NO3
Phân tử khối
289.3694
Monoisotopic mass
289.167793607
InChI
InChI=1S/C17H23NO3/c1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12/h2-6,13-16,19H,7-11H2,1H3/t13-,14+,15+,16?
InChI Key
InChIKey=RKUNBYITZUJHSG-SPUOUPEWSA-N
IUPAC Name
(1R,3S,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl 3-hydroxy-2-phenylpropanoate
Traditional IUPAC Name
atropine
SMILES
CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)C(CO)C1=CC=CC=C1
Độ tan chảy
118.5 °C
Độ hòa tan
2200 mg/L (at 25 °C)
logP
1.83
logS
-2.12
pKa (strongest acidic)
15.15
pKa (Strongest Basic)
9.39
PSA
49.77 Å2
Refractivity
80.82 m3·mol-1
Polarizability
31.28 Å3
Rotatable Bond Count
5
H Bond Acceptor Count
3
H Bond Donor Count
1
Physiological Charge
1
Number of Rings
3
Bioavailability
1
Rule of Five
true
Ghose Filter
true
pKa
9.43
Dược Lực Học : Atropine, a naturally occurring belladonna alkaloid, is a racemic mixture of equal parts of d- and l-hyoscyamine, whose activity is due almost entirely to the levo isomer of the drug. Atropine is commonly classified as an anticholinergic or antiparasympathetic (parasympatholytic) drug. More precisely, however, it is termed an antimuscarinic agent since it antagonizes the muscarine-like actions of acetylcholine and other choline esters. Adequate doses of atropine abolish various types of reflex vagal cardiac slowing or asystole. The drug also prevents or abolishes bradycardia or asystole produced by injection of choline esters, anticholinesterase agents or other parasympathomimetic drugs, and cardiac arrest produced by stimulation of the vagus. Atropine may also lessen the degree of partial heart block when vagal activity is an etiologic factor. Atropine in clinical doses counteracts the peripheral dilatation and abrupt decrease in blood pressure produced by choline esters. However, when given by itself, atropine does not exert a striking or uniform effect on blood vessels or blood pressure.
Cơ Chế Tác Dụng : An alkaloid, originally from Atropa belladonna, but found in other plants, mainly solanaceae. [PubChem] Atropine binds to and inhibit muscarinic acetylcholine receptors, producing a wide range of anticholinergic effects.
Dược Động Học :
▧ Absorption :
Atropine is rapidly and well absorbed after intramuscular administration. Atropine disappears rapidly from the blood and is distributed throughout the various body tissues and fluids.
▧ Protein binding :
The protein binding of atropine is 14 to 22% in plasma.
▧ Metabolism :
Much of the drug is destroyed by enzymatic hydrolysis, particularly in the liver. From 13 to 50% is excreted unchanged in the urine.
▧ Route of Elimination :
Much of the drug is destroyed by enzymatic hydrolysis, particularly in the liver; from 13 to 50% is excreted unchanged in the urine.
▧ Half Life :
3.0 ± 0.9 hours in adults. The half-life of atropine is slightly shorter (approximately 20 minutes) in females than males.
Độc Tính : Oral, mouse: LD50 = 75 mg/kg. Symptoms of overdose includes widespread paralysis of parasympathetically innervated organs. Dry mucous membranes, widely dilated and nonresponsive pupils, tachycardia, fever and cutaneous flush are especially prominent, as are mental and neurological symptoms. In instances of severe intoxication, respiratory depression, coma, circulatory collapse and death may occur.
Chỉ Định : For the treatment of poisoning by susceptible organophosphorous nerve agents having cholinesterase activity as well as organophosphorous or carbamate insecticides.
Tương Tác Thuốc :
  • Cinitapride Anticholinergic agents like atropine may reduce the action of cinitapride.
  • Donepezil Possible antagonism of action
  • Galantamine Possible antagonism of action
  • Haloperidol The anticholinergic increases the risk of psychosis and tardive dyskinesia
  • Tacrine The therapeutic effects of the central acetylcholinesterase inhibitor, Tacrine, and/or the anticholinergic, Atropine, may be reduced due to antagonism. The interaction may be beneficial when the anticholinergic action is a side effect. Monitor for decreased efficacy of both agents.
  • Trimethobenzamide Trimethobenzamide and Atropine, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Monitor for enhanced anticholinergic effects.
  • Triprolidine Triprolidine and Atropine, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Monitor for enhanced anticholinergic effects.
  • Trospium Trospium and Atropine, two anticholinergics, may cause additive anticholinergic effects and enhanced adverse/toxic effects. Monitor for enhanced anticholinergic effects.
Liều Lượng & Cách Dùng : Liquid - Ophthalmic
Liquid - Oral
Ointment - Ophthalmic
Solution - Intramuscular
Solution - Intravenous
Solution - Ophthalmic
Solution / drops - Oral
Tablet - Oral
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Sản phẩm biệt dược : Anespin
  • Công ty : Ying Yuan
    Sản phẩm biệt dược : Antol
  • Công ty : Meridian
    Sản phẩm biệt dược : AtroPen
  • Công ty : Sigma
    Sản phẩm biệt dược : Atropt
  • Công ty : Fischer
    Sản phẩm biệt dược : Atrospan
  • Công ty : Farmapol
    Sản phẩm biệt dược : Bellapan
  • Công ty : MaxMedic
    Sản phẩm biệt dược : Dysurgal
  • Công ty : Synpac-Kingdom
    Sản phẩm biệt dược : Kintropine
  • Công ty : The Central
    Sản phẩm biệt dược : Tromine
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00572
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C01479
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00113
BindingDB
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50241332
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/63739-458-21
PharmGKB
http://www.pharmgkb.org/drug/PA448505
Wikipedia
http://en.wikipedia.org/wiki/Atropine
RxList
http://www.rxlist.com/cgi/generic3/atropen.htm
Drugs.com
http://www.drugs.com/cdi/atropine-drops.html
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