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Các tên gọi khác (14 ) :
  • 1-Methyl N-L-alpha-aspartyl-L-phenylalanate
  • 1-Methyl N-L-alpha-aspartyl-L-phenylalanine
  • 1-methyl N-L-α-aspartyl-L-phenylalanate
  • 3-Amino-N-(alpha-carboxyphenethyl)succinamic acid N-methyl ester
  • 3-Amino-N-(alpha-methoxycarbonylphenethyl) succinamic acid
  • 3-Amino-N-(α-carboxyphenethyl)succinamic acid N-methyl ester
  • 3-Amino-N-(α-methoxycarbonylphenethyl) succinamic acid
  • Asp-phe-ome
  • Aspartam
  • Aspartame
  • Aspartamo
  • Aspartamum
  • Aspartylphenylalanine methyl ester
  • L-Aspartyl-L-phenylalanine methyl ester
Thực phẩm chức năng
Thuốc Gốc
Small Molecule
CAS: 22839-47-0
ĐG : Medisca Inc. , http://www.medisca.com
CTHH: C14H18N2O5
PTK: 294.3031
Flavoring agent sweeter than sugar, metabolized as phenylalanine and aspartic acid. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
Phân tử khối
Monoisotopic mass
InChI Key
(3S)-3-amino-3-{[(2S)-1-methoxy-1-oxo-3-phenylpropan-2-yl]carbamoyl}propanoic acid
Traditional IUPAC Name
COC(=O)[[email protected]](CC1=CC=CC=C1)NC(=O)[[email protected]@H](N)CC(O)=O
Độ tan chảy
about 190 and 245-247
Độ hòa tan
The solubility of aspartame in water is dependent on pH and temperature, the maximum solubility is reached at pH 2.2 (20 mg/mL at 25 °C) and the minimum solubility at pH 5.2 (pHi) is 13.5 mg/mL at 25 °C.
pKa (strongest acidic)
pKa (Strongest Basic)
118.72 Å2
73.22 m3·mol-1
29.58 Å3
Rotatable Bond Count
H Bond Acceptor Count
H Bond Donor Count
Physiological Charge
Number of Rings
Rule of Five
Dược Lực Học : Aspartame (L-alpha-aspartyl-L-phenylalanine methyl ester) is a low-calorie sweetener used to sweeten a wide variety of low- and reduced-calorie foods and beverages, including low-calorie tabletop sweeteners. Aspartame is composed of two amino acids, aspartic acid and phenylalanine, as the methyl ester. Aspartic acid and phenylalanine are also found naturally in protein containing foods, including meats, grains and dairy products. Methyl esters are also found naturally in many foods such as fruits and vegetable and their juices. Upon digestion, aspartame breaks down into three components (aspartic acid, phenylalanine and methanol), which are then absorbed into the blood and used in normal body processes. Neither aspartame nor its components accumulates in the body. These components are used in the body in the same ways as when they are derived from common foods.
Cơ Chế Tác Dụng : Flavoring agent sweeter than sugar, metabolized as phenylalanine and aspartic acid. [PubChem] 180 to 200 times sweeter than sucrose, it is metabolized as a protein and its subsequent amino-acids used up in there respective mechanisms.
Dược Động Học :
▧ Absorption :
Absorbed in the small intestine, aspartame is metabolized and absorbed very quickly.
▧ Metabolism :
Approximately 10% of aspartame (by weight) is broken down into methanol in the small intestine. Most of the methanol is absorbed and quickly converted into formaldehyde. Approximately 50% of aspartame (by weight) is broken down into phenylalanine. Approximately 40% of aspartame (by mass) is broken down into aspartic acid.
▧ Half Life :
At room temperature, aspartame is most stable at pH 4.3, where its half-life is nearly 300 days. At pH 7 however, its half-life is only a few days.
Độc Tính : Mild gastrointestinal side effects including diarrhea have been reported.
Chỉ Định : Used as a diet supplement and sugar substitute.
Dữ Kiện Thương Mại
Giá thị trường
  • Biệt dược thương mại : Aspartame powder
    Giá bán buôn : USD >1.68
    Đơn vị tính : g
Nhà Sản Xuất
  • Công ty : Ajinomoto
    Sản phẩm biệt dược : Aminosweet
  • Công ty : Merisant
    Sản phẩm biệt dược : Canderel
  • Công ty : Merisant
    Sản phẩm biệt dược : Equal
  • Công ty : NutraSweet
    Sản phẩm biệt dược : Nutrasweet
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