Tìm theo
Arsthinol
Các tên gọi khác (1) :
  • Arsthinenol
Thuốc Gốc
Small Molecule
CAS: 119-96-0
CTHH: C11H14AsNO3S2
PTK: 347.285
Arsthinol (INN) is an antiprotozoal agent. It was synthesized for the first time in 1949 by Ernst A.H. Friedheim by complexation of acetarsol with 2,3-dimercaptopropanol (British anti-Lewisite) and has been demonstrated to be effective against amoebiasis and yaws. It was marketed few years latter by Endo Products (Balarsen, Tablets, 0.1 g). Among trivalent organoarsenicals, arthinol was considered as very well tolerated. Recently, it was studied for its anticancer activity. [Wikipedia]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C11H14AsNO3S2
Phân tử khối
347.285
Monoisotopic mass
346.963106116
InChI
InChI=1/C11H14AsNO3S2/c1-7(15)13-10-4-8(2-3-11(10)16)12-17-6-9(5-14)18-12/h2-4,9,14,16H,5-6H2,1H3,(H,13,15)
InChI Key
InChIKey=MRUDSZSRLQAPOG-UHFFFAOYNA-N
IUPAC Name
N-{2-hydroxy-5-[4-(hydroxymethyl)-1,3,2-dithiarsolan-2-yl]phenyl}acetamide
Traditional IUPAC Name
arsthinol
SMILES
CC(=O)NC1=CC(=CC=C1O)[As]1SCC(CO)S1
logP
1.11
pKa (strongest acidic)
8.52
pKa (Strongest Basic)
-2.8
PSA
69.56 Å2
Refractivity
73.33 m3·mol-1
Polarizability
30.92 Å3
Rotatable Bond Count
3
H Bond Acceptor Count
3
H Bond Donor Count
3
Physiological Charge
0
Number of Rings
2
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Động Học :

▧ Metabolism :
89% Hepatic
Độc Tính : Oral,mouse: LD50 = 300 mg/kg; Oral, rabbit: LD50 = 3200 mg/kg; Oral, rat: LD50 = 980 mg/kg.
Chỉ Định : Antiprotozoal agent effective against amoebiasis and yaws.
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty : Endo Products
    Sản phẩm biệt dược : Balarsen
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB08928
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D07356
Wikipedia
http://en.wikipedia.org/wiki/Arsthinol
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