Tìm theo
Arimoclomol
Thuốc Gốc
Small Molecule
CAS: 289893-25-0
CTHH: C14H20ClN3O3
PTK: 313.78
Arimoclomol is an experimental drug compound developed by CytRx Corporation, a biopharmaceutical company based in Los Angeles, California. The orally administered drug is intended to treat amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, a neurodegenerative disease with no effective treatment.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C14H20ClN3O3
Phân tử khối
313.78
Monoisotopic mass
313.119319228
InChI
InChI=1S/C14H20ClN3O3/c15-14(12-5-4-8-18(20)9-12)16-21-11-13(19)10-17-6-2-1-3-7-17/h4-5,8-9,13,19H,1-3,6-7,10-11H2/b16-14-/t13-/m1/s1
InChI Key
InChIKey=SGEIEGAXKLMUIZ-XUVDNFPMSA-N
IUPAC Name
3-[chloro({[(2R)-2-hydroxy-3-(piperidin-1-yl)propoxy]imino})methyl]pyridin-1-ium-1-olate
Traditional IUPAC Name
3-[chloro({[(2R)-2-hydroxy-3-(piperidin-1-yl)propoxy]imino})methyl]pyridin-1-ium-1-olate
SMILES
O[C@@H](CON=C(Cl)C1=C[N+]([O-])=CC=C1)CN1CCCCC1
Độ hòa tan
2.37e-01 g/l
logP
0.31
logS
-3.1
pKa (strongest acidic)
14
pKa (Strongest Basic)
9.14
PSA
70.52 Å2
Refractivity
83.13 m3·mol-1
Polarizability
32.93 Å3
Rotatable Bond Count
6
H Bond Acceptor Count
5
H Bond Donor Count
1
Physiological Charge
1
Number of Rings
2
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Cơ Chế Tác Dụng : Arimoclomol is an experimental drug compound developed by CytRx Corporation, a biopharmaceutical company based in Los Angeles, California. The orally administered drug is intended to treat amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, a neurodegenerative disease with no effective treatment. Arimoclomol is designed to stimulate a natural cellular repair pathway by activating compounds called “molecular chaperones.” Arimoclomol uses a unique 'molecular chaperone' co-induction mechanism. The small molecule drug candidate is believed to function by stimulating a normal cellular protein repair pathway through the activation of "molecular chaperones." Since damaged proteins called aggregates are thought to play a role in many diseases, CytRx believes that activation of molecular chaperones could have therapeutic efficacy for a broad range of diseases.
Độc Tính : R Upregulation of heat shock proteins rescues motoneurones from axotomy-induced cell death in neonatal rats. Exp Neurol
Chỉ Định : Investigated for use/treatment in amyotrophic lateral sclerosis (ALS), diabetes mellitus type 2, neurologic disorders, and neuropathy (diabetic).
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB05025
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=208924
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=783757
ChemSpider
http://www.chemspider.com/Chemical-Structure.181020.html
Wikipedia
http://en.wikipedia.org/wiki/Arimoclomol
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