Tìm theo
Arbutamine
Các tên gọi khác (2) :
  • Arbutamina
  • Arbutaminum
Thuốc Gốc
Small Molecule
CAS: 128470-16-6
ATC: C01CA22
CTHH: C18H23NO4
PTK: 317.3795
Arbutamine, administered through a closed-loop, computer-controlled drug-delivery system, is indicated to elicit acute cardiovascular responses, similar to those produced by exercise, in order to aid in diagnosing the presence or absence of coronary artery disease in patients who cannot exercise adequately .
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C18H23NO4
Phân tử khối
317.3795
Monoisotopic mass
317.162708229
InChI
InChI=1S/C18H23NO4/c20-15-7-4-13(5-8-15)3-1-2-10-19-12-18(23)14-6-9-16(21)17(22)11-14/h4-9,11,18-23H,1-3,10,12H2/t18-/m0/s1
InChI Key
InChIKey=IIRWWTKISYTTBL-SFHVURJKSA-N
IUPAC Name
4-[(1R)-1-hydroxy-2-{[4-(4-hydroxyphenyl)butyl]amino}ethyl]benzene-1,2-diol
Traditional IUPAC Name
arbutamine
SMILES
O[C@@H](CNCCCCC1=CC=C(O)C=C1)C1=CC(O)=C(O)C=C1
Độ hòa tan
8.42e-02 g/l
logP
2.9
logS
-3.6
pKa (strongest acidic)
8.97
pKa (Strongest Basic)
9.76
PSA
92.95 Å2
Refractivity
89.78 m3·mol-1
Polarizability
35.54 Å3
Rotatable Bond Count
8
H Bond Acceptor Count
5
H Bond Donor Count
5
Physiological Charge
1
Number of Rings
2
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Cơ Chế Tác Dụng : Arbutamine, administered through a closed-loop, computer-controlled drug-delivery system, is indicated to elicit acute cardiovascular responses, similar to those produced by exercise, in order to aid in diagnosing the presence or absence of coronary artery disease in patients who cannot exercise adequately . Arbutamine is a synthetic catecholamine with positive chronotropic and inotropic properties. The chronotropic (increase in heart rate) and inotropic (increase in force of contraction) effects of arbutamine serve to mimic exercise by increasing cardiac work (producing stress) and provoke myocardial ischemia in patients with compromised coronary arteries. The increase in heart rate caused by arbutamine is thought to limit regional subendocardial perfusion, thereby limiting tissue oxygenation. In functional assays, arbutamine is more selective for beta-adrenergic receptors than for alpha-adrenergic receptors. The beta-agonist activity of arbutamine provides cardiac stress by increasing heart rate, cardiac contractility, and systolic blood pressure. The degree of hypotension that occurs for a given chronotropic activity is less with arbutamine than, for example, with isoproterenol because alpha receptor activity is retained.
Dược Động Học :

▧ Protein binding :
58%
▧ Metabolism :
Primarily metabolized to methoxyarbutamine. Another possible metabolite is ketoarbutamine. The metabolites of arbutamine appear to have less pharmacological activity and a longer half-life and than the parental drug.
▧ Half Life :
Elimination half-life is approximately 8 minutes.
Chỉ Định : Used to elicit acute cardiovascular responses (cardiac stumulant), similar to those produced by exercise, in order to aid in diagnosing the presence or absence of coronary artery disease (CAD) in patients who cannot exercise adequately.
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : GenESA
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01102
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=60789
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46509010
ChemSpider
http://www.chemspider.com/Chemical-Structure.54785.html
PharmGKB
http://www.pharmgkb.org/drug/PA164747979
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