Tìm theo
Antrafenine
Các tên gọi khác (1) :
  • Antrafenine
Thuốc Gốc
Small Molecule
CAS: 55300-30-6
CTHH: C30H26F6N4O2
PTK: 588.5435
Antrafenine is a piperazine derivative drug that acts as an analgesic and anti-inflammatory drug with similar efficacy to naproxen. It is not widely used as it has largely been replaced by newer drugs.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C30H26F6N4O2
Phân tử khối
588.5435
Monoisotopic mass
588.195995326
InChI
InChI=1S/C30H26F6N4O2/c31-29(32,33)20-4-3-5-22(18-20)40-14-12-39(13-15-40)16-17-42-28(41)24-6-1-2-7-25(24)38-26-10-11-37-27-19-21(30(34,35)36)8-9-23(26)27/h1-11,18-19H,12-17H2,(H,37,38)
InChI Key
InChIKey=NWGGKKGAFZIVBJ-UHFFFAOYSA-N
IUPAC Name
2-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}ethyl 2-{[7-(trifluoromethyl)quinolin-4-yl]amino}benzoate
Traditional IUPAC Name
antrafenine
SMILES
FC(F)(F)C1=CC(=CC=C1)N1CCN(CCOC(=O)C2=CC=CC=C2NC2=C3C=CC(=CC3=NC=C2)C(F)(F)F)CC1
Độ tan chảy
88-90
Độ hòa tan
2.84e-03 g/l
logP
8.39
logS
-5.3
pKa (strongest acidic)
16.69
pKa (Strongest Basic)
7.04
PSA
57.7 Å2
Refractivity
147.01 m3·mol-1
Polarizability
55.48 Å3
Rotatable Bond Count
10
H Bond Acceptor Count
5
H Bond Donor Count
1
Physiological Charge
0
Number of Rings
5
Bioavailability
0
MDDR-Like Rule
true
Dược Lực Học : Its mode of action is not fully understood; however, its ability to inhibit prostaglandin synthesis may be involved in the anti-inflammatory effect.
Cơ Chế Tác Dụng : Antrafenine is a piperazine derivative drug that acts as an analgesic and anti-inflammatory drug with similar efficacy to naproxen. It is not widely used as it has largely been replaced by newer drugs. Antrafenine is believed to be associated with the inhibition of cyclooxygenase activity. Two unique cyclooxygenases have been described in mammals. The constitutive cyclooxygenase, COX-1, synthesizes prostaglandins necessary for normal gastrointestinal and renal function. The inducible cyclooxygenase, COX-2, generates prostaglandins involved in inflammation. Inhibition of COX-1 is thought to be associated with gastrointestinal and renal toxicity while inhibition of COX-2 provides anti-inflammatory activity.
Chỉ Định : Antrafenine is used as an anti-inflammatory and analgesic agent for the relief of mild to moderate pain.
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Stakane
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01419
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=68723
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46507354
ChemSpider
http://www.chemspider.com/Chemical-Structure.61973.html
PharmGKB
http://www.pharmgkb.org/drug/PA164784000
Wikipedia
http://en.wikipedia.org/wiki/Antrafenine
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