Tìm theo
Antithymocyte globulin
Các tên gọi khác (3) :
  • rabbit ATG
  • rATG
  • Thymoglobulin
immunologic factors, immunosuppressive agents
Thuốc Gốc
Biotech
ĐG : Genzyme Inc. , http://www.genzyme.ca
Rabbit anti-thymocyte globulin. Thymoglobulin is a polyclonal antibody that suppresses certain types of immune cells responsible for acute organ rejection in transplant patients. Thymoglobulin is a mixture of antibodies intended to bind to various cell surface antigens. The most common mode of action of Thymoglobulin is via selective depletion of T-cells.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Độ tan chảy
61 °C (FAB fragment), 71 °C (whole mAb)
Dược Lực Học : Antithymocyte Globulin (ATG)is a concentrated anti-human T-lymphocyte immunoglobulin preparation derived from rabbits after immunization with a T-lympoblast cell line. ATG is an immunosuppressive product for the prevention and treatment of acute rejection following organ transplantation. ATG reduces the host immune response against tissue transplants or organ allografts.
Cơ Chế Tác Dụng : Rabbit anti-thymocyte globulin. Thymoglobulin is a polyclonal antibody that suppresses certain types of immune cells responsible for acute organ rejection in transplant patients. Thymoglobulin is a mixture of antibodies intended to bind to various cell surface antigens. The most common mode of action of Thymoglobulin is via selective depletion of T-cells. Binds to multiple, T-cell specific antigens leading to T-lymphocyte cell death via complement mediated cytotoxicity or apoptosis.
Dược Động Học :
▧ Absorption :
T-cell depletion usually observed within 1 day after initiating therapy. Average 21.5 and 87 mcg/mL 4–8 hours post-infusion after first and last IV doses, respectively, when given for 7–11 days.
▧ Metabolism :
Most likely removed by opsonization via the reticuloendothelial system when bound to T lymphocytes, or by human antimurine antibody production.
▧ Half Life :
2-3 days, may increase after multiple doses administration
Độc Tính : Not known whether ATG (rabbit) distributes into human milk; however, other immunoglobulins are distributed into human milk.
Chỉ Định : For prevention of renal transplant rejection
Tương Tác Thuốc :
  • Canakinumab results in increased immunosuppressive effects; increases the risk of infection.
  • Denosumab Monitor therapy because of the enhanced immunosuppressive effect and increased risk of infections.
  • Leflunomide Therapy modification may be required because the combination enhances toxic effects of leflunomide.
  • Natalizumab Avoid combination due to enhanced toxic effects of natalizumab.
  • Pimecrolimus Avoid combination due to enhanced immunosuppressive effects and increased risk of infections.
  • Rilonacept results in increased immunosuppressive effects; increases the risk of infection.
  • Roflumilast Therapy may need to be modified due to enhanced immunosuppressive effects.
  • Sipuleucel-T Monitor therapy due to potential decreased therapeutic effect of sipuleucel-T.
  • Tacrolimus Avoid combination due to increased immunosuppressive effects
  • Tofacitinib Avoid combination due to enhanced immunosuppressive effects.
  • Trastuzumab Monitor therapy due to enhanced neutropenic effect
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty : Fresenius SE
    Sản phẩm biệt dược : ATG-Fresenius
  • Công ty : Fresenius SE
    Sản phẩm biệt dược : ATG-Fresenius S
  • Công ty :
    Sản phẩm biệt dược : Genzyme
  • Công ty :
    Sản phẩm biệt dược : Thymoglobulin SangStat Medical
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00098
PharmGKB
http://www.pharmgkb.org/drug/PA164743704
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