Tìm theo
Antipyrine
Các tên gọi khác (8 ) :
  • 1,2-Dihydro-1,5-dimethyl-2-phenyl-3H-pyrazol-3-one
  • 2,3-Dimethyl-1-phenyl-5-pyrazolone
  • Analgesine
  • Antipyrine
  • Fenazon
  • Fenazona
  • Phenazon
  • Phenazone
anti inflammatory agents non steroidal
Thuốc Gốc
Small Molecule
CAS: 60-80-0
ATC: N02BB01, S02DA03
ĐG : Deston Therapeutics , http://www.deston.com
CTHH: C11H12N2O
PTK: 188.2258
An analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (From Martindale, The Extra Pharmacopoeia, 30th ed, p29)
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C11H12N2O
Phân tử khối
188.2258
Monoisotopic mass
188.094963016
InChI
InChI=1S/C11H12N2O/c1-9-8-11(14)13(12(9)2)10-6-4-3-5-7-10/h3-8H,1-2H3
InChI Key
InChIKey=VEQOALNAAJBPNY-UHFFFAOYSA-N
IUPAC Name
1,5-dimethyl-2-phenyl-2,3-dihydro-1H-pyrazol-3-one
Traditional IUPAC Name
antipyrine
SMILES
CN1N(C(=O)C=C1C)C1=CC=CC=C1
Độ tan chảy
114 °C
Độ sôi
319 °C
Độ hòa tan
5.19E+004 mg/L (at 25 °C)
logP
0.38
logS
-0.6
pKa (Strongest Basic)
0.37
PSA
23.55 Å2
Refractivity
56.42 m3·mol-1
Polarizability
20.4 Å3
Rotatable Bond Count
1
H Bond Acceptor Count
2
H Bond Donor Count
0
Physiological Charge
0
Number of Rings
2
Bioavailability
1
Rule of Five
true
Ghose Filter
true
caco2 Permeability
-4.55
pKa
1.4
Dược Lực Học : Antipyrine is an analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (From Martindale, The Extra Pharmacopoeia, 30th ed, p29)
Cơ Chế Tác Dụng : An analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (From Martindale, The Extra Pharmacopoeia, 30th ed, p29) Antipyrine is thought to act primarily in the CNS, increasing the pain threshold by inhibiting both isoforms of cyclooxygenase, COX-1, COX-2, and COX-3 enzymes involved in prostaglandin (PG) synthesis.
Chỉ Định : Antipyrine is an analgesic often used to test effects of other drugs on liver enzymes..
Liều Lượng & Cách Dùng : Solution / drops - Oral
Solution / drops - Oral
Dữ Kiện Thương Mại
Giá thị trường
  • Biệt dược thương mại : Auralgan ear drops
    Giá bán buôn : USD >13.11
    Đơn vị tính : ml
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01435
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=2206
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46505216
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D01776
ChemSpider
http://www.chemspider.com/Chemical-Structure.2121.html
PharmGKB
http://www.pharmgkb.org/drug/PA448453
Wikipedia
http://en.wikipedia.org/wiki/Phenazone
PDRhealth
http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/ant1656.shtml
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