Tìm theo
Antazoline
Các tên gọi khác (5 ) :
  • Antazoline
  • SID11112519
  • SID11113348
  • SID124882433
  • Vasocon-a
Thuốc chống dị ứng
Thuốc Gốc
Small Molecule
CAS: 91-75-8
ATC: R01AC04
CTHH: C17H19N3
PTK: 265.3529
Antazoline is a 1st generation antihistamine that also anticholinergic properties used to relieve nasal congestion and in eye drops, usually in combination with naphazoline, to relieve the symptoms of allergic conjunctivitis.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C17H19N3
Phân tử khối
265.3529
Monoisotopic mass
265.157897623
InChI
InChI=1S/C17H19N3/c1-3-7-15(8-4-1)13-20(14-17-18-11-12-19-17)16-9-5-2-6-10-16/h1-10H,11-14H2,(H,18,19)
InChI Key
InChIKey=REYFJDPCWQRWAA-UHFFFAOYSA-N
IUPAC Name
N-benzyl-N-(4,5-dihydro-1H-imidazol-2-ylmethyl)aniline
Traditional IUPAC Name
antazoline
SMILES
C(N(CC1=CC=CC=C1)C1=CC=CC=C1)C1=NCCN1
Độ tan chảy
227-229
Độ hòa tan
663 mg/L (at 30 °C)
logP
2.88
logS
-3.4
pKa (Strongest Basic)
9.24
PSA
27.63 Å2
Refractivity
82.89 m3·mol-1
Polarizability
30.11 Å3
Rotatable Bond Count
5
H Bond Acceptor Count
3
H Bond Donor Count
1
Physiological Charge
1
Number of Rings
3
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Antazoline is a histamine H1 receptor antagonist. It selectively bind to but does not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine.
Cơ Chế Tác Dụng : Antazoline is a 1st generation antihistamine that also anticholinergic properties used to relieve nasal congestion and in eye drops, usually in combination with naphazoline, to relieve the symptoms of allergic conjunctivitis. Antazoline binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine.
Chỉ Định : Used to relieve nasal congestion and in eye drops, usually in combination with naphazoline, to relieve the symptoms of allergic conjunctivitis.
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB08799
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D07458
ChemSpider
http://www.chemspider.com/Chemical-Structure.2115.html
PharmGKB
http://www.pharmgkb.org/drug/PA165958418
Wikipedia
http://en.wikipedia.org/wiki/Antazoline
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