Tìm theo
Anistreplase
Các tên gọi khác (4 ) :
  • t- PA
  • t-plasminogen activator
  • Tissue-type plasminogen activator precursor
  • tPA
fibrinolytic agents, thrombolytic agents
Thuốc Gốc
Biotech
CAS: 81669-57-0
ATC: B01AD03
ĐG : Haupt Pharma , http://haupt-pharma.de
CTHH: C2569H3928N746O781S40
PTK: 59042.3000
Human tissue plasminogen activator, purified, glycosylated, 527 residues purified from CHO cells. Eminase is a lyophilized (freeze-dried) formulation of anistreplase, the p-anisoyl derivative of the primary Lys-plasminogen-streptokinase activator complex (a complex of Lys-plasminogen and streptokinase). A p-anisoyl group is chemically conjugated to a complex of bacterial-derived streptokinase and human Plasma-derived Lys-plasminogen proteins.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C2569H3928N746O781S40
Phân tử khối
59042.3000
Độ tan chảy
60 °C
Độ kỵ nước
-0.516
Điểm đẳng điện tích
7.61
Dược Lực Học : Anistreplase cleaves the Arg/Val bond in plasminogen to form plasmin. Plasmin in turn degrades the fibrin matrix of the thrombus, thereby exerting its thrombolytic action. This helps eliminate blood clots or arterial blockages that cause myocardial infarction.
Cơ Chế Tác Dụng : Human tissue plasminogen activator, purified, glycosylated, 527 residues purified from CHO cells. Eminase is a lyophilized (freeze-dried) formulation of anistreplase, the p-anisoyl derivative of the primary Lys-plasminogen-streptokinase activator complex (a complex of Lys-plasminogen and streptokinase). A p-anisoyl group is chemically conjugated to a complex of bacterial-derived streptokinase and human Plasma-derived Lys-plasminogen proteins. Anistreplase cleaves the Arg/Val bond in plasminogen to form plasmin. This in turn leads to the degradation of blood clots.
Chỉ Định : For lysis of acute pulmonary emboli, intracoronary emboli and management of myocardial infarction
Liều Lượng & Cách Dùng : Powder, for solution - Intravenous
Dữ Kiện Thương Mại
Nhà Sản Xuất
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00029
GenBank
http://www.ncbi.nlm.nih.gov/nuccore/L00153
PharmGKB
http://www.pharmgkb.org/drug/PA164769075
Wikipedia
http://en.wikipedia.org/wiki/Anistreplase
... loading
... loading