Tìm theo
Anisotropine Methylbromide
Các tên gọi khác (11 ) :
  • 8-Methyl-3-(2-propylpentanoyloxy)tropinium bromide
  • 8-Methyltropinium bromide 2-propylpentanoate
  • 8-Methyltropinium bromide 2-propylvalerate
  • Anisotropine methobromide
  • Anisotropine methylbromide
  • Endo-8,8-dimethyl-3-((1-oxo-2-propylpentyl)oxy)-8-azoniabicyclo(3.2.1)octane bromide
  • Methylbromure d'octatropine
  • Methyloctatropine bromide
  • Metilbromuro de octatropina
  • Octatropine methylbromide
  • Octatropini methylbromidum
muscarinic antagonists, cholinergic antagonists
Thuốc Gốc
Small Molecule
CAS: 80-50-2
CTHH: C17H32BrNO2
PTK: 362.345
Anisotropine methylbromide is a quaternary ammonium compound. Its use as treatment adjunct in peptic ulcer has been replaced by the use of more effective agents. Depending on the dose, anisotropine methylbromide may reduce the motility and secretory activity of the gastrointestinal system, and the tone of the ureter and urinary bladder and may have a slight relaxant action on the bile ducts and gallbladder. In general, smaller doses of anisotropine methylbromide inhibit salivary and bronchial secretions, sweating, and accommodation; cause dilatation of the pupil; and increase the heart rate. Larger doses are required to decrease motility of the gastrointestinal and urinary tracts and to inhibit gastric acid secretion.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C17H32BrNO2
Phân tử khối
362.345
Monoisotopic mass
361.16164192
InChI
InChI=1S/C17H32NO2.BrH/c1-5-7-13(8-6-2)17(19)20-16-11-14-9-10-15(12-16)18(14,3)4;/h13-16H,5-12H2,1-4H3;1H/q+1;/p-1
InChI Key
InChIKey=QSFKGMJOKUZAJM-UHFFFAOYSA-M
IUPAC Name
(3S)-8,8-dimethyl-3-[(2-propylpentanoyl)oxy]-8-azabicyclo[3.2.1]octan-8-ium bromide
Traditional IUPAC Name
(3S)-8,8-dimethyl-3-[(2-propylpentanoyl)oxy]-8-azabicyclo[3.2.1]octan-8-ium bromide
SMILES
[Br-].CCCC(CCC)C(=O)O[C@H]1CC2CCC(C1)[N+]2(C)C
Độ tan chảy
329 °C
Độ hòa tan
1600 mg/L
logP
0.60
logS
-6.6
pKa (Strongest Basic)
-7.1
PSA
26.3 Å2
Refractivity
93.26 m3·mol-1
Polarizability
34.09 Å3
Rotatable Bond Count
7
H Bond Acceptor Count
1
H Bond Donor Count
0
Physiological Charge
1
Number of Rings
2
Bioavailability
1
Rule of Five
true
Dược Lực Học : Anisotropine methylbromide is a quaternary ammonium compound. Its use as treatment adjunct in peptic ulcer has been replaced by the use of more effective agents. Depending on the dose, anisotropine methylbromide may reduce the motility and secretory activity of the gastrointestinal system, and the tone of the ureter and urinary bladder and may have a slight relaxant action on the bile ducts and gallbladder. In general, smaller doses of anisotropine methylbromide inhibit salivary and bronchial secretions, sweating, and accommodation; cause dilatation of the pupil; and increase the heart rate. Larger doses are required to decrease motility of the gastrointestinal and urinary tracts and to inhibit gastric acid secretion.
Cơ Chế Tác Dụng : Anisotropine methylbromide is a quaternary ammonium compound. Its use as treatment adjunct in peptic ulcer has been replaced by the use of more effective agents. Depending on the dose, anisotropine methylbromide may reduce the motility and secretory activity of the gastrointestinal system, and the tone of the ureter and urinary bladder and may have a slight relaxant action on the bile ducts and gallbladder. In general, smaller doses of anisotropine methylbromide inhibit salivary and bronchial secretions, sweating, and accommodation; cause dilatation of the pupil; and increase the heart rate. Larger doses are required to decrease motility of the gastrointestinal and urinary tracts and to inhibit gastric acid secretion. Quaternary ammonium compounds such as anisotropine methylbromide inhibit the muscarinic actions of acetylcholine on structures innervated by postganglionic cholinergic nerves as well as on smooth muscles that respond to acetylcholine but lack cholinergic innervation. These postganglionic receptor sites are present in the autonomic effector cells of the smooth muscle, cardiac muscle, sinoatrial and atrioventricular nodes, and exocrine glands.
Dược Động Học :
▧ Absorption :
Gastrointestinal absorption is poor and irregular. Total absorption after an oral dose is about 10 to 25%.
▧ Protein binding :
Not Known
▧ Metabolism :
Hepatic, by enzymatic hydrolysis.
▧ Half Life :
Not Known
Chỉ Định : For use in conjunction with antacids or histamine H2-receptor antagonists in the treatment of peptic ulcer, to reduce further gastric acid secretion and delay gastric emptying.
Tương Tác Thuốc :
  • Haloperidol The anticholinergic increases the risk of psychosis and tardive dyskinesia
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Endovalpin
  • Công ty :
    Sản phẩm biệt dược : Lytispasm
  • Công ty : Endo
    Sản phẩm biệt dược : Valpin
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00517
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C06830
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00232
PharmGKB
http://www.pharmgkb.org/drug/PA164754880
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