Tìm theo
anecortave acetate
Thuốc Gốc
Small Molecule
CTHH: C23H30O5
PTK: 386.4813
Anecortave acetate (Retaane) is an analog of cortisol acetate; among the modifications to the steroid are the removal of the 11ß hydroxyl OH group and an addition of a 21-acetate group. As a result of these modifications, anecortave acetate lacks the typical antiinflammatory and immunosuppressive properties of glucocorticoids.Alcon Inc. is developing and marketing Retaane.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C23H30O5
Phân tử khối
386.4813
Monoisotopic mass
386.20932407
InChI
InChI=1S/C23H30O5/c1-14(24)28-13-20(26)23(27)11-8-19-17-5-4-15-12-16(25)6-9-21(15,2)18(17)7-10-22(19,23)3/h7,12,17,19,27H,4-6,8-11,13H2,1-3H3/t17-,19+,21+,22+,23+/m1/s1
InChI Key
InChIKey=YUWPMEXLKGOSBF-GACAOOTBSA-N
IUPAC Name
2-[(2S,10S,11S,14R,15S)-14-hydroxy-2,15-dimethyl-5-oxotetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-1(17),6-dien-14-yl]-2-oxoethyl acetate
Traditional IUPAC Name
anecortave
SMILES
[H][C@@]12CC[C@](O)(C(=O)COC(C)=O)[C@@]1(C)CC=C1[C@@]2([H])CCC2=CC(=O)CC[C@]12C
Độ hòa tan
1.13e-02 g/l
logP
2.62
logS
-4.5
pKa (strongest acidic)
12.61
pKa (Strongest Basic)
-3.8
PSA
80.67 Å2
Refractivity
105.81 m3·mol-1
Polarizability
42.44 Å3
Rotatable Bond Count
4
H Bond Acceptor Count
4
H Bond Donor Count
1
Physiological Charge
0
Number of Rings
4
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Cơ Chế Tác Dụng : Anecortave acetate (Retaane) is an analog of cortisol acetate; among the modifications to the steroid are the removal of the 11ß hydroxyl OH group and an addition of a 21-acetate group. As a result of these modifications, anecortave acetate lacks the typical antiinflammatory and immunosuppressive properties of glucocorticoids.Alcon Inc. is developing and marketing Retaane. Anecortave acetate functions as an antiangiogenic agent, inhibiting blood vessel growth by decreasing extracellular protease expression and inhibiting endothelial cell migration. Its angiostatic activity does not seem to be mediated through any of the commonly known pharmacological receptors. (Ophthalmology 2004;111:2316-7) RETAANE blocks signals from multiple growth factors because it acts downstream and independent of the initiating angiogenic stimuli and inhibits angiogenesis subsequent to the angiogenic stimulation.
Chỉ Định : Investigated for use/treatment in glaucoma and macular degeneration.
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Retaane
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB05288
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=111332
ChemSpider
http://www.chemspider.com/Chemical-Structure.99892.html
Wikipedia
http://en.wikipedia.org/wiki/Anecortave
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