Tìm theo
Amyl Nitrite
Các tên gọi khác (8 ) :
  • 1-Nitropentane
  • Amyl nitrite
  • Amyl nitrosum
  • Isoamyl nitrite
  • n-Amyl nitrite
  • n-pentyl nitrite
  • Nitramyl
  • Pentyl nitrite
Thuốc tim mạch
Thuốc Gốc
Small Molecule
CAS: 110-46-3
ATC: V03AB22
ĐG : James Alexander Corp. , http://www.james-alexander.com
CTHH: C5H11NO2
PTK: 117.1463
Amyl Nitrite is an antihypertensive medicine. Amyl nitrite is employed medically to treat heart diseases such as angina and to treat cyanide poisoning. Like other alkyl nitrites, amyl nitrite is bioactive in mammals, being a vasodilator which is the basis of its use as a prescription medicine. As an inhalant, it also has psychoactive effect which has led to illegal drug use.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C5H11NO2
Phân tử khối
117.1463
Monoisotopic mass
117.078978601
InChI
InChI=1S/C5H11NO2/c1-2-3-4-5-8-6-7/h2-5H2,1H3
InChI Key
InChIKey=CSDTZUBPSYWZDX-UHFFFAOYSA-N
IUPAC Name
pentyl nitrite
Traditional IUPAC Name
amyl nitrite
SMILES
CCCCCON=O
Độ hòa tan
3.97e+00 g/l
logP
2.31
logS
-1.5
pKa (Strongest Basic)
-1.8
PSA
38.66 Å2
Refractivity
31.68 m3·mol-1
Polarizability
12.84 Å3
Rotatable Bond Count
5
H Bond Acceptor Count
2
H Bond Donor Count
0
Physiological Charge
0
Number of Rings
0
Bioavailability
1
Rule of Five
true
Dược Lực Học : Amyl nitrite, in common with other alkyl nitrites, is a potent vasodilator. It expands blood vessels, resulting in lowering of the blood pressure. Alkyl nitrite functions as a source of nitric oxide, which signals for relaxation of the involuntary muscles. Physical effects include decrease in blood pressure, headache, flushing of the face, increased heart rate, dizziness, and relaxation of involuntary muscles, especially the blood vessel walls and the anal sphincter. There are no withdrawal symptoms.
Cơ Chế Tác Dụng : Amyl Nitrite is an antihypertensive medicine. Amyl nitrite is employed medically to treat heart diseases such as angina and to treat cyanide poisoning. Like other alkyl nitrites, amyl nitrite is bioactive in mammals, being a vasodilator which is the basis of its use as a prescription medicine. As an inhalant, it also has psychoactive effect which has led to illegal drug use. Amyl nitrite's antianginal action is thought to be the result of a reduction in systemic and pulmonary arterial pressure (afterload) and decreased cardiac output because of peripheral vasodilation, rather than coronary artery dilation. Amyl nitrite is a source of nitric acid, which accounts for the mechanism described above. As an antidote (to cyanide poisoning), amyl nitrite promotes formation of methemoglobin, which combines with cyanide to form nontoxic cyanmethemoglobin.
Dược Động Học :
▧ Absorption :
Amyl nitrite vapors are absorbed rapidly through the pulmonary alveoli, manifesting therapeutic effects within one minute after inhalation.
▧ Metabolism :
Hepatic. The drug is metabolized rapidly, probably by hydrolytic denitration; approximately one-third of the inhaled amyl nitrite is excreted in the urine.
Độc Tính : Overdose symptoms include nausea, emesis (vomiting), hypotension, hypoventilation, dyspnea (shortness of breath), and syncope (fainting)
Chỉ Định : For the rapid relief of angina pectoris.
Tương Tác Thuốc :
Liều Lượng & Cách Dùng : Liquid - Oral
Tablet - Oral
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Aspiral
  • Công ty :
    Sản phẩm biệt dược : Vaporole
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01612
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C07457
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00517
PharmGKB
http://www.pharmgkb.org/drug/PA164750570
Wikipedia
http://en.wikipedia.org/wiki/Amyl_nitrite
RxList
http://www.rxlist.com/cgi/generic/amylnitrite.htm
Drugs.com
http://www.drugs.com/cons/amyl-nitrite-inhalation-oral-nebulization.html
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