Tìm theo
Amrinone
Các tên gọi khác (4 ) :
  • Amcoral
  • Amrinona
  • Amrinonum
  • Inamrinone
cardiotonic agents, phosphodiesterase 3 inhibitors, vasodilator agents, calcium channel blockers
Thuốc Gốc
Small Molecule
CAS: 60719-84-8
ATC: C01CE01
ĐG : Bedford Labs , http://www.bedfordlabs.com
CTHH: C10H9N3O
PTK: 187.198
Amrinone (or inamrinone) is a type 3 pyridine phosphodiesterase inhibitor. It is used in the treatment of congestive heart failure.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C10H9N3O
Phân tử khối
187.198
Monoisotopic mass
187.074561925
InChI
InChI=1S/C10H9N3O/c11-9-5-8(6-13-10(9)14)7-1-3-12-4-2-7/h1-6H,11H2,(H,13,14)
InChI Key
InChIKey=RNLQIBCLLYYYFJ-UHFFFAOYSA-N
IUPAC Name
3-amino-5-(pyridin-4-yl)-1,2-dihydropyridin-2-one
Traditional IUPAC Name
amrinone
SMILES
NC1=CC(=CNC1=O)C1=CC=NC=C1
Độ tan chảy
294-297
Độ hòa tan
5.60e+00 g/l
logP
-0.57
logS
-1.5
pKa (strongest acidic)
11.01
pKa (Strongest Basic)
4.87
PSA
68.01 Å2
Refractivity
53.89 m3·mol-1
Polarizability
18.94 Å3
Rotatable Bond Count
1
H Bond Acceptor Count
3
H Bond Donor Count
2
Physiological Charge
0
Number of Rings
2
Bioavailability
1
Rule of Five
true
Dược Lực Học : Amrinone is a positive inotropic cardiotonic with vasodilator properties, phosphodiesterase inhibitory activity, and the ability to stimulate calcium ion influx into the cardiac cell.
Cơ Chế Tác Dụng : Amrinone (or inamrinone) is a type 3 pyridine phosphodiesterase inhibitor. It is used in the treatment of congestive heart failure. Amrinone is a phosphodiesterase inhibitor (PDE3), resulting in increased cAMP and cGMP which leads to an increase in the calcium influx like that caused by beta-agonists resulting in increased inotropic effect.
Dược Động Học :

▧ Volume of Distribution :
* 1.2 L/kg [normal volunteers]
▧ Protein binding :
10 to 49%
▧ Metabolism :
Hepatic.
▧ Route of Elimination :
The primary route of excretion in man is via the urine as both inamrinone and several metabolites (N-glycolyl, N-acetate, O-glucuronide and N-glucuronide).
▧ Half Life :
5 to 8 hours
Chỉ Định : Used in the treatment of congestive heart failure.
Liều Lượng & Cách Dùng : Liquid - Intravenous bolus
Liquid - Intravenous drip
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Amcoral
  • Công ty :
    Sản phẩm biệt dược : Inocor
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01427
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=3698
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46504647
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C13594
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00231
ChemSpider
http://www.chemspider.com/Chemical-Structure.3570.html
BindingDB
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=34651
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/55390-042-10
PharmGKB
http://www.pharmgkb.org/drug/PA164746803
Wikipedia
http://en.wikipedia.org/wiki/Amrinone
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