Tìm theo
Ampicillin
Các tên gọi khác (18 ) :
  • (2S,5R,6R)-6-{[(2R)-2-amino-2-phenylacetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
  • (2S,5R,6R)-6-{[(2R)-2-amino-2-phenylethanoyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
  • 6-(D-(2-amino-2-Phenylacetamido))-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid
  • ABPC
  • Aminobenzylpenicillin
  • AMP
  • Ampicilina
  • Ampicillin
  • Ampicillin Acid
  • Ampicillin Anhydrous
  • Ampicilline
  • Ampicillinum
  • Anhydrous ampicillin
  • AP
  • D-(-)-6-(alpha-Aminophenylacetamido)penicillanic acid
  • D-(-)-Ampicillin
  • D-(−)-6-(α-aminophenylacetamido)penicillanic acid
  • D-(−)-ampicillin
Thuốc trị ký sinh trùng, chống nhiễm khuẩn
Thuốc Gốc
Small Molecule
CAS: 69-53-4
ATC: J01CA01, J01CA02, J01CA06, J01CA14, J01CA15, S01AA19
ĐG : American Antibiotics LLC
CTHH: C16H19N3O4S
PTK: 349.405
Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C16H19N3O4S
Phân tử khối
349.405
Monoisotopic mass
349.109626801
InChI
InChI=1S/C16H19N3O4S/c1-16(2)11(15(22)23)19-13(21)10(14(19)24-16)18-12(20)9(17)8-6-4-3-5-7-8/h3-7,9-11,14H,17H2,1-2H3,(H,18,20)(H,22,23)/t9-,10-,11+,14-/m1/s1
InChI Key
InChIKey=AVKUERGKIZMTKX-NJBDSQKTSA-N
IUPAC Name
(2S,5R,6R)-6-[(2R)-2-amino-2-phenylacetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Traditional IUPAC Name
ampicillin
SMILES
[H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)[C@H](N)C1=CC=CC=C1)C(O)=O
Độ tan chảy
208 dec °C
Độ hòa tan
1.01E+004 mg/L (at 21 °C)
logP
1.35
logS
-2.8
pKa (strongest acidic)
3.24
pKa (Strongest Basic)
7.44
PSA
112.73 Å2
Refractivity
87.52 m3·mol-1
Polarizability
34.54 Å3
Rotatable Bond Count
4
H Bond Acceptor Count
5
H Bond Donor Count
3
Physiological Charge
0
Number of Rings
3
Bioavailability
1
Rule of Five
true
Dược Lực Học : Ampicillin is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. The name "penicillin" can either refer to several variants of penicillin available, or to the group of antibiotics derived from the penicillins. Ampicillin has in vitro activity against gram-positive and gram-negative aerobic and anaerobic bacteria. The bactericidal activity of Ampicillin results from the inhibition of cell wall synthesis and is mediated through Ampicillin binding to penicillin binding proteins (PBPs). Ampicillin is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, and cephalosporinases and extended spectrum beta-lactamases.
Cơ Chế Tác Dụng : Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic. [PubChem] By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, Ampicillin inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that Ampicillin interferes with an autolysin inhibitor.
Dược Động Học :

▧ Route of Elimination :
Ampicillin is excreted largely unchanged in the urine.
Chỉ Định : For treatment of infection (Respiratory, GI, UTI and meningitis) due to E. coli, P. mirabilis, enterococci, Shigella, S. typhosa and other Salmonella, nonpenicillinase-producing N. gononhoeae, H. influenzae, staphylococci, streptococci including streptoc
Tương Tác Thuốc :
Liều Lượng & Cách Dùng : Capsule - Oral
Liquid - Oral
Powder, for solution - Intramuscular
Powder, for solution - Intravenous
Powder, for solution - Oral
Suspension - Oral
Tablet - Oral
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Sản phẩm biệt dược : Austrapen
  • Công ty : Bayer
    Sản phẩm biệt dược : Binotal
  • Công ty : GlaxoSmithKline
    Sản phẩm biệt dược : Penbritin
  • Công ty :
    Sản phẩm biệt dược : Principen
  • Công ty : Meiji
    Sản phẩm biệt dược : Viccillin
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00415
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=6249
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46505346
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C06574
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00204
ChemSpider
http://www.chemspider.com/Chemical-Structure.6013.html
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0781-3412-92
PharmGKB
http://www.pharmgkb.org/drug/PA448419
Wikipedia
http://en.wikipedia.org/wiki/Ampicillin
RxList
http://www.rxlist.com/cgi/generic/ampicillin.htm
Drugs.com
http://www.drugs.com/cdi/ampicillin.html
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