Tìm theo
Amperozide
Thuốc Gốc
Small Molecule
CAS: 75558-90-6
CTHH: C23H29F2N3O
PTK: 401.4927
Amperozide is an atypical antipsychotic of the diphenylbutylpiperazine class which acts as an antagonist at the 5-HT2A receptor. It does not block dopamine receptors as with most antipsychotic drugs, but does inhibit dopamine release, and alters the firing pattern of dopaminergic neurons. It was investigated for the treatment of schizophrenia in humans, but never adopted clinically, its main use is instead in veterinary medicine, primarily in intensively farmed pigs, for decreasing aggression and stress and thereby increasing feeding and productivity. [Wikipedia]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C23H29F2N3O
Phân tử khối
401.4927
Monoisotopic mass
401.227868975
InChI
InChI=1S/C23H29F2N3O/c1-2-26-23(29)28-16-14-27(15-17-28)13-3-4-22(18-5-9-20(24)10-6-18)19-7-11-21(25)12-8-19/h5-12,22H,2-4,13-17H2,1H3,(H,26,29)
InChI Key
InChIKey=NNAIYOXJNVGUOM-UHFFFAOYSA-N
IUPAC Name
4-[4,4-bis(4-fluorophenyl)butyl]-N-ethylpiperazine-1-carboxamide
Traditional IUPAC Name
amperozide
SMILES
[H]N(CC)C(=O)N1CCN(CCCC(C2=CC=C(F)C=C2)C2=CC=C(F)C=C2)CC1
logP
4.12
pKa (strongest acidic)
15.61
pKa (Strongest Basic)
7.56
PSA
35.58 Å2
Refractivity
112.28 m3·mol-1
Polarizability
43.52 Å3
Rotatable Bond Count
7
H Bond Acceptor Count
2
H Bond Donor Count
1
Physiological Charge
1
Number of Rings
3
Bioavailability
1
Rule of Five
true
Ghose Filter
true
MDDR-Like Rule
true
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB08927
Wikipedia
http://en.wikipedia.org/wiki/Amperozide
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