Tìm theo
Amonafide
Thuốc Gốc
Small Molecule
CAS: 69408-81-7
CTHH: C16H17N3O2
PTK: 283.3251
Amonafide is a substance that is being studied in the treatment of cancer. It belongs to the families of drugs called topoisomerase inhibitors and intercalating agents.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C16H17N3O2
Phân tử khối
283.3251
Monoisotopic mass
283.132076803
InChI
InChI=1S/C16H17N3O2/c1-18(2)6-7-19-15(20)12-5-3-4-10-8-11(17)9-13(14(10)12)16(19)21/h3-5,8-9H,6-7,17H2,1-2H3
InChI Key
InChIKey=UPALIKSFLSVKIS-UHFFFAOYSA-N
IUPAC Name
11-amino-3-[2-(dimethylamino)ethyl]-3-azatricyclo[7.3.1.0^{5,13}]trideca-1(13),5,7,9,11-pentaene-2,4-dione
Traditional IUPAC Name
11-amino-3-[2-(dimethylamino)ethyl]-3-azatricyclo[7.3.1.0^{5,13}]trideca-1(13),5,7,9,11-pentaene-2,4-dione
SMILES
CN(C)CCN1C(=O)C2=CC=CC3=CC(N)=CC(C1=O)=C23
Độ hòa tan
7.64e-01 g/l
logP
1.1
logS
-2.6
pKa (Strongest Basic)
8.52
PSA
66.64 Å2
Refractivity
83.38 m3·mol-1
Polarizability
30.1 Å3
Rotatable Bond Count
3
H Bond Acceptor Count
4
H Bond Donor Count
1
Physiological Charge
1
Number of Rings
3
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Cơ Chế Tác Dụng : Amonafide is a substance that is being studied in the treatment of cancer. It belongs to the families of drugs called topoisomerase inhibitors and intercalating agents. Amonafide is a DNA intercalating agent and inhibitor of topoisomerase II that has been extensively studied in patients with malignant solid tumors. Amonafide has also been studied in patients with AML.
Chỉ Định : Investigated for use/treatment in breast cancer, ovarian cancer, and prostate cancer.
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Quinamed
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB05022
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=50515
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=10346677
ChemSpider
http://www.chemspider.com/Chemical-Structure.45804.html
BindingDB
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50033894
... loading
... loading