Tìm theo
Amisulpride
Các tên gọi khác (5 ) :
  • 4-Amino-N-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-2-methoxybenzamide
  • 4-Amino-N-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-O-anisamide
  • Aminosultopride
  • Amisulprida
  • Amisulpridum
Thuốc điều trị về tâm thần
Thuốc Gốc
Small Molecule
CAS: 53583-79-2
ATC: N05AL05
CTHH: C17H27N3O4S
PTK: 369.479
Amisulpride (trade name Solian) is an antipsychotic drug sold by Sanofi-Aventis. It is not approved for use in the United States, but is approved for use in Europe and Australia for the treatment of psychoses and schizophrenia. Additionally, it is approved in Italy for the treatment of dysthymia (under the brand name Deniban). Amisulpride is a selective dopamine antagonist.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C17H27N3O4S
Phân tử khối
369.479
Monoisotopic mass
369.172227057
InChI
InChI=1S/C17H27N3O4S/c1-4-20-8-6-7-12(20)11-19-17(21)13-9-16(25(22,23)5-2)14(18)10-15(13)24-3/h9-10,12H,4-8,11,18H2,1-3H3,(H,19,21)
InChI Key
InChIKey=NTJOBXMMWNYJFB-UHFFFAOYSA-N
IUPAC Name
4-amino-5-(ethanesulfonyl)-N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxybenzamide
Traditional IUPAC Name
amisulpride
SMILES
CCN1CCCC1CNC(=O)C1=CC(=C(N)C=C1OC)S(=O)(=O)CC
Độ tan chảy
181-182 °C
Độ hòa tan
2.93e-01 g/l
logP
1.06
logS
-3.1
pKa (strongest acidic)
14.03
pKa (Strongest Basic)
7.05
PSA
101.73 Å2
Refractivity
99.84 m3·mol-1
Polarizability
39.82 Å3
Rotatable Bond Count
7
H Bond Acceptor Count
6
H Bond Donor Count
2
Physiological Charge
1
Number of Rings
2
Bioavailability
1
Rule of Five
true
Ghose Filter
true
pKa
9.37
Cơ Chế Tác Dụng : Amisulpride (trade name Solian) is an antipsychotic drug sold by Sanofi-Aventis. It is not approved for use in the United States, but is approved for use in Europe and Australia for the treatment of psychoses and schizophrenia. Additionally, it is approved in Italy for the treatment of dysthymia (under the brand name Deniban). Amisulpride is a selective dopamine antagonist. Amisulpride binds selectively to dopamine D(2) and D(3) receptors in the limbic system. Low doses of amisulpride preferentially block presynaptic D(2)/D(3)-dopamine autoreceptors, thereby enhancing dopaminergic transmission, whereas higher doses block postsynaptic receptors, thus inhibiting dopaminergic hyperactivity. It may also have 5-ht7 antagonistic effect, useful in depression treatment.
Dược Động Học :
▧ Absorption :
Bioavailability is 48% following oral administration.
▧ Protein binding :
Low (17%)
▧ Half Life :
Approximately 12 hours
Độc Tính : Overdoses of amisulpride have been linked with torsades de pointes.
Chỉ Định : Investigated for use/treatment in schizophrenia and schizoaffective disorders, mania in bipolar disorder, and depression.
Dữ Kiện Thương Mại
Nhà Sản Xuất
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB06288
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=2159
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=99443244
ChemSpider
http://www.chemspider.com/Chemical-Structure.2074.html
PharmGKB
http://www.pharmgkb.org/drug/PA162565877
Wikipedia
http://en.wikipedia.org/wiki/Amisulpride
... loading
... loading