Tìm theo
Aminophenazone
Các tên gọi khác (25 ) :
  • (Dimethylamino)phenazone
  • 1-Phenyl-2,3-dimethyl-4-(dimethylamino)-5-pyrazolone
  • 1-Phenyl-2,3-dimethyl-4-dimethylaminopyrazol-5-one
  • 1,5-Dimethyl-4-dimethylamino-2-phenyl-3-pyrazolone
  • 2,3-Dimethyl-4-dimethylamino-1-phenyl-5-pyrazolone
  • 3-Keto-1,5-dimethyl-4-dimethylamino-2-phenyl-2,3-dihydropyrazole
  • 4-(Dimethylamino)-1,2-dihydro-1,5-dimethyl-2-phenyl-3H-pyrazol-3-one
  • 4-(Dimethylamino)-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one
  • 4-(Dimethylamino)antipyrine
  • 4-Dimethylamino-1-phenyl-2,3-dimethylpyrazolone
  • 4-Dimethylamino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one
  • 4-Dimethylamino-2,3-dimethyl-1-phenyl-5-pyrazolone
  • 4-Dimethylaminoantipyrine
  • 4-Dimethylaminophenazone
  • Aminofenazona
  • Aminofenazone
  • Aminophenazon
  • Aminophenazonum
  • Aminopyrine
  • Dimethylaminoantipyrine
  • Dimethylaminoazophene
  • Dimethylaminophenazon
  • Dimethylaminophenazone
  • Dimethylaminophenyldimethylpyrazolone
  • Dipyrine
pyrazolones
Thuốc Gốc
Small Molecule
CAS: 58-15-1
ATC: N02BB03
CTHH: C13H17N3O
PTK: 231.2936
A pyrazolone with analgesic, anti-inflammatory, and antipyretic properties but has risk of agranulocytosis. A breath test with 13C-labeled aminopyrine has been used as a non-invasive measure of cytochrome P-450 metabolic activity in liver function tests. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C13H17N3O
Phân tử khối
231.2936
Monoisotopic mass
231.137162181
InChI
InChI=1S/C13H17N3O/c1-10-12(14(2)3)13(17)16(15(10)4)11-8-6-5-7-9-11/h5-9H,1-4H3
InChI Key
InChIKey=RMMXTBMQSGEXHJ-UHFFFAOYSA-N
IUPAC Name
4-(dimethylamino)-1,5-dimethyl-2-phenyl-2,3-dihydro-1H-pyrazol-3-one
Traditional IUPAC Name
aminophenazone
SMILES
CN(C)C1=C(C)N(C)N(C1=O)C1=CC=CC=C1
Độ tan chảy
134.5 °C
Độ hòa tan
5.44E+004 mg/L (at 30 °C)
logP
1.00
logS
-0.63
pKa (Strongest Basic)
3.47
PSA
26.79 Å2
Refractivity
70.11 m3·mol-1
Polarizability
25.87 Å3
Rotatable Bond Count
2
H Bond Acceptor Count
3
H Bond Donor Count
0
Physiological Charge
0
Number of Rings
2
Bioavailability
1
Rule of Five
true
Ghose Filter
true
caco2 Permeability
-4.44
pKa
5
Dược Lực Học : Aminophenazone is a pyrazolone with analgesic, anti-inflammatory, and antipyretic properties but has risk of agranulocytosis. A breath test with 13C-labeled aminopyrine has been used as a non-invasive measure of cytochrome P-450 metabolic activity in liver function tests. [Wikipedia]
Cơ Chế Tác Dụng : A pyrazolone with analgesic, anti-inflammatory, and antipyretic properties but has risk of agranulocytosis. A breath test with 13C-labeled aminopyrine has been used as a non-invasive measure of cytochrome P-450 metabolic activity in liver function tests. [PubChem] Aminophenazone is metabolized very slowly by normal newborn babies. In older infants, a higher amount of exhaled 13-CO2 is observed.
Độc Tính : Can cause life-threatening agranulocytosis.
Chỉ Định : Formerly widely used as an antipyretic and analgesic in rheumatism, neuritis, and common colds. Currently used to measure total body water.
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01424
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=6009
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46504975
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C07539
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00556
ChemSpider
http://www.chemspider.com/Chemical-Structure.5787.html
PharmGKB
http://www.pharmgkb.org/drug/PA164748135
Wikipedia
http://en.wikipedia.org/wiki/Aminophenazone
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