Tìm theo
Aminolevulinic acid
Các tên gọi khác (12 ) :
  • 5-ALA
  • 5-Amino-4-oxopentanoate
  • 5-Amino-4-oxovaleric acid
  • 5-Aminolevulinate
  • 5-Aminolevulinic acid
  • ALA
  • ALA-PDT
  • Aminolevulinate
  • Aminolevulinic acid
  • DALA
  • delta-ALA
  • delta-Aminolevulinic acid
Thuốc cản quang dùng trong chẩn đoán X-Quang
Thuốc Gốc
Small Molecule
CAS: 106-60-5
ATC: L01XD04
ĐG : Dusa Pharmaceuticals , http://www.dusapharma.com
CTHH: C5H9NO3
PTK: 131.1299
A compound produced from succinyl-CoA and glycine as an intermediate in heme synthesis. It is used as a photochemotherapy for actinic keratosis. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C5H9NO3
Phân tử khối
131.1299
Monoisotopic mass
131.058243159
InChI
InChI=1S/C5H9NO3/c6-3-4(7)1-2-5(8)9/h1-3,6H2,(H,8,9)
InChI Key
InChIKey=ZGXJTSGNIOSYLO-UHFFFAOYSA-N
IUPAC Name
5-amino-4-oxopentanoic acid
Traditional IUPAC Name
aminolevulinic acid
SMILES
NCC(=O)CCC(O)=O
Độ tan chảy
156-158 °C
Độ hòa tan
Very soluble
logP
-1.5
logS
0.12
pKa (strongest acidic)
4.05
pKa (Strongest Basic)
7.84
PSA
80.39 Å2
Refractivity
30.45 m3·mol-1
Polarizability
12.55 Å3
Rotatable Bond Count
4
H Bond Acceptor Count
4
H Bond Donor Count
2
Physiological Charge
0
Number of Rings
0
Bioavailability
1
Rule of Five
true
Dược Lực Học : The metabolism of aminolevulinic acid (ALA) is the first step in the biochemical pathway resulting in heme synthesis. Aminolevulinic acid is not a photosensitizer, but rather a metabolic precursor of protoporphyrin IX (PpIX), which is a photosensitizer. The synthesis of ALA is normally tightly controlled by feedback inhibition of the enzyme, ALA synthetase, presumably by intracellular heme levels. ALA, when provided to the cell, bypasses this control point and results in the accumulation of PpIX, which is converted into heme by ferrochelatase through the addition of iron to the PpIX nucleus.
Cơ Chế Tác Dụng : A compound produced from succinyl-CoA and glycine as an intermediate in heme synthesis. It is used as a photochemotherapy for actinic keratosis. [PubChem] According to the presumed mechanism of action, photosensitization following application of aminolevulinic acid (ALA) topical solution occurs through the metabolic conversion of ALA to protoporphyrin IX (PpIX), which accumulates in the skin to which aminolevulinic acid has been applied. When exposed to light of appropriate wavelength and energy, the accumulated PpIX produces a photodynamic reaction, a cytotoxic process dependent upon the simultaneous presence of light and oxygen. The absorption of light results in an excited state of the porphyrin molecule, and subsequent spin transfer from PpIX to molecular oxygen generates singlet oxygen, which can further react to form superoxide and hydroxyl radicals. Photosensitization of actinic (solar) keratosis lesions using aminolevulinic acid, plus illumination with the BLU-UTM Blue Light Photodynamic Therapy Illuminator (BLU-U), is the basis for aminolevulinic acid photodynamic therapy (PDT).
Dược Động Học :
▧ Absorption :
Oral bioavailability is 50-60%.
▧ Metabolism :
Following topical administration, synthesis into protoporphyrin IX takes place in situ in the skin.
▧ Half Life :
Mean half-life is 0.70 ± 0.18 h after the oral dose and 0.83 ± 0.05 h after the intravenous dose.
Độc Tính : Solution overdose have not been reported.
Chỉ Định : Aminolevulinic acid plus blue light illumination using a blue light photodynamic therapy illuminator is indicated for the treatment of minimally to moderately thick actinic keratoses of the face or scalp.
Liều Lượng & Cách Dùng : Powder, for solution - Topical
Dữ Kiện Thương Mại
Giá thị trường
  • Biệt dược thương mại : Levulan kerastick
    Giá bán buôn : USD >170.25
    Đơn vị tính : each
Nhà Sản Xuất
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00855
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=137
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46506856
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C00430
ChemSpider
http://www.chemspider.com/Chemical-Structure.134.html
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/67308-101-01
PharmGKB
http://www.pharmgkb.org/drug/PA10015
Wikipedia
http://en.wikipedia.org/wiki/Aminolevulinic_acid
RxList
http://www.rxlist.com/cgi/generic3/levulan.htm
Drugs.com
http://www.drugs.com/cdi/aminolevulinic-acid-solution.html
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