Tìm theo
Aminohippurate
Các tên gọi khác (11 ) :
  • 4-Aminohippuric acid
  • Aminohippuric acid
  • N-(P-Aminobenzoyl)aminoacetic acid
  • N-(P-Aminobenzoyl)glycine
  • N-(Para-aminobenzoyl)glycine
  • P-Aminohippurate
  • PAH
  • Paha
  • para-aminohippurate
  • para-aminohippuric acid
  • Paraaminohippuric acid
indicators and reagents, diagnostic agents
Thuốc Gốc
Small Molecule
CAS: 94-16-6
ATC: V04CH30
ĐG : Merck & Co. , http://www.merck.com
CTHH: C9H10N2O3
PTK: 194.1873
The glycine amide of 4-aminobenzoic acid. Its sodium salt is used as a diagnostic aid to measure effective renal plasma flow (ERPF) and excretory capacity. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
Phân tử khối
194.1873
Monoisotopic mass
194.069142196
InChI
InChI=1S/C9H10N2O3/c10-7-3-1-6(2-4-7)9(14)11-5-8(12)13/h1-4H,5,10H2,(H,11,14)(H,12,13)
InChI Key
InChIKey=HSMNQINEKMPTIC-UHFFFAOYSA-N
IUPAC Name
2-[(4-aminophenyl)formamido]acetic acid
Traditional IUPAC Name
aminohippurate
SMILES
NC1=CC=C(C=C1)C(=O)NCC(O)=O
Độ tan chảy
199-200 °C
Độ hòa tan
Slightly soluble
logP
-2.2
logS
-1.8
pKa (strongest acidic)
2.7
pKa (Strongest Basic)
4.24
PSA
92.42 Å2
Refractivity
50.82 m3·mol-1
Polarizability
19.13 Å3
Rotatable Bond Count
3
H Bond Acceptor Count
4
H Bond Donor Count
3
Physiological Charge
-1
Number of Rings
1
Bioavailability
1
Rule of Five
true
pKa
3.83
Dược Lực Học : Aminohippurate (p-aminohippuric acid, PAH, PAHA) is the glycine amide of p-aminobenzoic acid. It is filtered by the glomeruli and is actively secreted by the proximal tubules. At low plasma concentrations (1.0 to 2.0 mg/100 mL), an average of 90 percent of aminohippurate is cleared by the kidneys from the renal blood stream in a single circulation. It is ideally suited for measurement of ERPF since it has a high clearance, is essentially nontoxic at the plasma concentrations reached with recommended doses, and its analytical determination is relatively simple and accurate. Aminohippurate is also used to measure the functional capacity of the renal tubular secretory mechanism or transport maximum (TmPAH). This is accomplished by elevating the plasma concentration to levels (40-60 mg/100 mL) sufficient to saturate the maximal capacity of the tubular cells to secrete aminohippurate. Inulin clearance is generally measured during TmPAH determinations since glomerular filtration rate (GFR) must be known before calculations of secretory Tm measurements can be done.
Cơ Chế Tác Dụng : The glycine amide of 4-aminobenzoic acid. Its sodium salt is used as a diagnostic aid to measure effective renal plasma flow (ERPF) and excretory capacity. [PubChem] Aminohippurate is filtered by the renal glomeruli and secreted into the urine by the proximal tubules. By measuring the amount of drug in the urine it is possible to determine functional capacity and effective renal plasma flow.
Độc Tính : The intravenous LD50 in female mice is 7.22 g/kg.
Chỉ Định : Used to measure effective renal plasma flow (ERPF) and to determine the functional capacity of the tubular excretory mechanism.
Liều Lượng & Cách Dùng : Injection, solution - Intravenous
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