Tìm theo
Amfecloral
Các tên gọi khác (1) :
  • Amphecloral
Thuốc Gốc
Small Molecule
CAS: 5581-35-1
CTHH: C11H12Cl3N
PTK: 264.579
Amfecloral (INN), also known as amphecloral (USAN), is a stimulant drug of the phenethylamine and amphetamine chemical classes that was used as an appetite suppressant under the trade name Acutran, but is now no longer marketed. It acts as a prodrug which splits to form amphetamine and chloral hydrate, similarly to clobenzorex and related compounds, except that the N-substituent in this case yields a compound that is active in its own right. The chloral hydrate metabolite is a gabaminergic sedative/hypnotic, and would in theory counteract some of the stimulant effects of the amphetamine metabolite. This would produce an effect similar to the amphetamine/barbiturate combinations previously used in psychiatric medications. [Wikipedia]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C11H12Cl3N
Phân tử khối
264.579
Monoisotopic mass
263.00353251
InChI
InChI=1/C11H12Cl3N/c1-9(15-8-11(12,13)14)7-10-5-3-2-4-6-10/h2-6,8-9H,7H2,1H3/b15-8+
InChI Key
InChIKey=VBZDETYCYXPOAK-OVCLIPMQNA-N
IUPAC Name
(E)-(1-phenylpropan-2-yl)(2,2,2-trichloroethylidene)amine
Traditional IUPAC Name
amfecloral
SMILES
CC(CC1=CC=CC=C1)\N=C\C(Cl)(Cl)Cl
logP
4.04
pKa (Strongest Basic)
4.36
PSA
12.36 Å2
Refractivity
67.97 m3·mol-1
Polarizability
25.36 Å3
Rotatable Bond Count
4
H Bond Acceptor Count
1
H Bond Donor Count
0
Physiological Charge
0
Number of Rings
1
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Chỉ Định : Used as an appetite suppressant.
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Acutran
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB08924
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D02926
... loading
... loading