Tìm theo
Amcinonide
Các tên gọi khác (3) :
  • Amcinonida
  • Amcinonidum
  • Triamcinolonacetatcyclopentanonid
glucocorticoids, corticosteroids
Thuốc Gốc
Small Molecule
CAS: 51022-69-6
ATC: D07AC11
ĐG : DPT Laboratories Ltd. , http://www.dptlabs.com
CTHH: C28H35FO7
PTK: 502.5717
Amcinonide is a corticosteroid. [Wikipedia]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
Phân tử khối
502.5717
Monoisotopic mass
502.236681679
InChI
InChI=1S/C28H35FO7/c1-16(30)34-15-22(33)28-23(35-26(36-28)9-4-5-10-26)13-20-19-7-6-17-12-18(31)8-11-24(17,2)27(19,29)21(32)14-25(20,28)3/h8,11-12,19-21,23,32H,4-7,9-10,13-15H2,1-3H3/t19-,20-,21-,23+,24-,25-,27-,28+/m0/s1
InChI Key
InChIKey=ILKJAFIWWBXGDU-MOGDOJJUSA-N
IUPAC Name
2-[(1'S,2'S,4'R,8'S,9'S,11'S,12'R,13'S)-12'-fluoro-11'-hydroxy-9',13'-dimethyl-16'-oxo-5',7'-dioxaspiro[cyclopentane-1,6'-pentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icosane]-14',17'-dien-8'-yl]-2-oxoethyl acetate
Traditional IUPAC Name
amcinonide
SMILES
[H][[email protected]@]12C[[email protected]@]3([H])[[email protected]]4([H])CCC5=CC(=O)C=C[[email protected]]5(C)[[email protected]@]4(F)[[email protected]@H](O)C[[email protected]]3(C)[[email protected]@]1(OC1(CCCC1)O2)C(=O)COC(C)=O
Độ hòa tan
7.74e-03 g/l
logP
2.3
logS
-4.8
pKa (strongest acidic)
13.63
pKa (Strongest Basic)
-3.4
PSA
99.13 Å2
Refractivity
127.88 m3·mol-1
Polarizability
52.23 Å3
Rotatable Bond Count
4
H Bond Acceptor Count
6
H Bond Donor Count
1
Physiological Charge
0
Number of Rings
6
Bioavailability
1
Dược Lực Học : Amcinonide is a topical corticosteroid. The topical corticosteroids constitute a class of primarily synthetic steroids used as anti-inflammatory and antipruritic agents. Amcinonide reduces or inhibits the actions of chemicals in the body that cause inflammation, redness, and swelling. The mechanism of anti-inflammatory activity of the topical corticosteroids is unclear. Various laboratory methods, including vasoconstrictor assays, are used to compare and predict potencies and/or clinical efficacies of the topical corticosteroids. There is some evidence to suggest that a recognizable correlation exists between vasoconstrictor potency and therapeutic efficacy in man. When in an ointment form, amcinonide also helps the skin maintain moisture.
Cơ Chế Tác Dụng : Amcinonide is a corticosteroid. [Wikipedia] The mechanism of the anti-inflammatory activity of the topical steroids, in general, is unclear. However, corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor, arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2. Amcinonide has affinity for the glucocorticoid receptor. It has weak affinity for the progesterone receptor, and virtually no affinity for the mineralocorticoid, estrogen, or androgen receptors.
Dược Động Học :
▧ Absorption :
Topical corticosteroids can be absorbed from normal intact skin. Inflammation and/or other disease processes in the skin increase percutaneous absorption.
▧ Metabolism :
Once absorbed through the skin, topical corticosteroids are handled through pharmacokinetic pathways similar to systemically administered corticosteroids. Corticosteroids are metabolized primarily in the liver and are then excreted by the kidneys.
▧ Route of Elimination :
Corticosteroids are metabolized primarily in the liver and are then excreted by the kidneys. Some of the topical corticosteroids and their metabolites are also excreted into the bile.
Độc Tính : Results from acute toxicity studies do not indicate that any risk of acute intoxication is to be expected following a single dermal application of an overdose (application over a large area under conditions favorable to absorption) or inadvertent oral ingestion.
Chỉ Định : For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.
Liều Lượng & Cách Dùng : Cream - Topical
Lotion - Topical
Ointment - Topical
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty : Wyeth
    Sản phẩm biệt dược : Cyclocort
  • Công ty :
    Sản phẩm biệt dược : Mycoderm
  • Công ty :
    Sản phẩm biệt dược : Penticort
  • Công ty :
    Sản phẩm biệt dược : Visderm
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