Tìm theo
Alverine
Các tên gọi khác (10 ) :
  • Alverina
  • Alverinum
  • Bis(gamma-phenylpropyl)ethylamine
  • Di(phenylpropyl)ethylamine
  • N-Ethyl-3-phenyl-N-(3-phenylpropyl)-1-propanamine
  • N-Ethyl-3,3'-diphenyldipropylamine
  • N-Ethyl-N-(3-phenylpropyl)benzenepropanamine
  • N,N-Bis(3-phenylpropyl)ethylamine
  • Phenopropamine
  • Phenpropamine
Thuốc đường tiêu hóa
Thuốc Gốc
Small Molecule
CAS: 150-59-4
ATC: A03AX08
CTHH: C20H27N
PTK: 281.4351
Alverine is a smooth muscle relaxant. Smooth muscle is a type of muscle that is not under voluntary control; it is the muscle present in places such as the gut and uterus. Alverine acts directly on the muscle in the gut, causing it to relax. This prevents the muscle spasms which occur in the gut in conditions such as irritable bowel syndrome and diverticular disease. It is used to relieve cramps or spasms of the stomach and intestines. It is also useful in treating irritable bowel syndrome (IBS) and similar conditions. It can also be used to help relieve period pain. Alverine is formulated as the citrate salt (5982-87-6).
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C20H27N
Phân tử khối
281.4351
Monoisotopic mass
281.214349869
InChI
InChI=1S/C20H27N/c1-2-21(17-9-15-19-11-5-3-6-12-19)18-10-16-20-13-7-4-8-14-20/h3-8,11-14H,2,9-10,15-18H2,1H3
InChI Key
InChIKey=ZPFXAOWNKLFJDN-UHFFFAOYSA-N
IUPAC Name
ethylbis(3-phenylpropyl)amine
Traditional IUPAC Name
alverine
SMILES
CCN(CCCC1=CC=CC=C1)CCCC1=CC=CC=C1
Độ tan chảy
< 25 °C
Độ sôi
212.5 °C at 1.30E+01 mm Hg
Độ hòa tan
9.60e-04 g/l
logP
5.46
logS
-5.5
pKa (Strongest Basic)
10.44
PSA
3.24 Å2
Refractivity
92.67 m3·mol-1
Polarizability
35.42 Å3
Rotatable Bond Count
9
H Bond Acceptor Count
1
H Bond Donor Count
0
Physiological Charge
1
Number of Rings
2
Bioavailability
1
Ghose Filter
true
Dược Lực Học : Alverine is a smooth muscle relaxant. Smooth muscle is a type of muscle that is not under voluntary control; it is the muscle present in places such as the gut and uterus. Alverine acts directly on the muscle in the gut, causing it to relax. This prevents the muscle spasms which occur in the gut in conditions such as irritable bowel syndrome and diverticular disease. Diverticular disease is a condition in which small pouches form in the gut lining. These pouches can trap particles of food and become inflamed and painful. In irritable bowel syndrome the normal activity of the gut muscle is lost. The muscle spasms result in symptoms such as heartburn, abdominal pain and bloating, constipation or diarrhoea. By relaxing the gut muscle, alverine citrate relieves the symptoms of this condition. Alverine also relaxes the smooth muscle in the womb (uterus). It is therefore also used to treat painful menstruation, which is caused by muscle spasms in the uterus (dysmenorrhea).
Dược Động Học :

▧ Metabolism :
Rapidly converted to its primary active metabolite, which is then further converted to two secondary metabolites.
▧ Route of Elimination :
High renal clearance of all metabolites indicating that they are eliminated by active renal secretion.
▧ Half Life :
The plasma half-life averages 0.8 hours for alverine and 5.7 hours for the active primary metabolite.
Độc Tính : Can produce hypotension and atropine-like toxic effects. Fatality has occurred following overdose with very high doses.
Chỉ Định : Used to relieve cramps or spasms of the stomach and intestines. It is also useful in treating irritable bowel syndrome (IBS) and similar conditions. It can also be used to help relieve period pain. Alverine citrate is also under investigation to increase the cytotoxic effects of the proteasome inhibitor MG132 on breast cancer cells.
Tương Tác Thuốc :
Liều Lượng & Cách Dùng : Capsule - Oral - 60mg
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Audmonal
  • Công ty :
    Sản phẩm biệt dược : Profenil
  • Công ty :
    Sản phẩm biệt dược : Spasmaverine
  • Công ty :
    Sản phẩm biệt dược : Spasmonal
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01616
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=3678
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46506981
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D07440
ChemSpider
http://www.chemspider.com/Chemical-Structure.3550.html
PharmGKB
http://www.pharmgkb.org/drug/PA164764505
Wikipedia
http://en.wikipedia.org/wiki/Alverine
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