Tìm theo
Alpha-methyltryptamine
Các tên gọi khác (7 ) :
  • 164E
  • 3-IT
  • AMT
  • Indopan
  • IT-290
  • IT-403
  • αMT
stimulants
Thuốc Gốc
Small Molecule
CAS: 299-26-3
CTHH: C11H14N2
PTK: 174.2423
A stimulant and psychoactive drug which produces effects similar to 3,4-methylenedioxy-N-methylamphetamine (MDMA), despite being structurally dissimilar. It was developed in the 1960's by Upjohn with the intention for use as an antidepressant. In the 1990's, alpha-methyltryptamine became regulated as a Schedule I controlled substance in the United states.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C11H14N2
Phân tử khối
174.2423
Monoisotopic mass
174.115698458
InChI
InChI=1S/C11H14N2/c1-8(12)6-9-7-13-11-5-3-2-4-10(9)11/h2-5,7-8,13H,6,12H2,1H3
InChI Key
InChIKey=QSQQQURBVYWZKJ-UHFFFAOYSA-N
IUPAC Name
1-(1H-indol-3-yl)propan-2-amine
Traditional IUPAC Name
α-methyltryptamine
SMILES
CC(N)CC1=CNC2=CC=CC=C12
Độ tan chảy
98-100 °C
Độ hòa tan
1.15e+00 g/l
logP
1.9
logS
-2.2
pKa (strongest acidic)
17.14
pKa (Strongest Basic)
9.96
PSA
41.81 Å2
Refractivity
54.79 m3·mol-1
Polarizability
20.19 Å3
Rotatable Bond Count
2
H Bond Acceptor Count
1
H Bond Donor Count
2
Physiological Charge
1
Number of Rings
2
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : With 20-30 milligrams, euphoria, empathy and psychedelic effects are noticeable. Side effects reported have included anxiety, restlessness, tachycardia, muscle tension, jaw tightness, headache, nausea, vomiting, and pupil dilation.
Độc Tính : Long lasting serotonin neuro-toxicity at high doses is potentially possible, and is seen with a close analogue of alpha-methyltryptmaine: alpha-ethyltryptamine.
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01446
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=9287
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46507024
ChemSpider
http://www.chemspider.com/Chemical-Structure.8930.html
BindingDB
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50014210
Wikipedia
http://en.wikipedia.org/wiki/Alpha-methyltryptamine
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