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Alpha-1-proteinase inhibitor
Các tên gọi khác (4 ) :
  • Alpha 1-antitrypsin
  • Alpha-1 protease inhibitor
  • Alpha-1-antiproteinase
  • Alpha-1-antitrypsin precursor
serine proteinase inhibitors, trypsin inhibitors, enzyme replacement agents
Thuốc Gốc
Biotech
CAS: 9041-92-3
ĐG : Baxter International Inc. , http://www.baxter.com
CTHH: C2001H3130N514O601S10
PTK: 44324.5000
Human alpha-1 proteinase inhibitor or alpha-1-antitrypsin, prepared from human plasma via Cohn alcohol fractionation followed by PEG and zinc chloride fractionation.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C2001H3130N514O601S10
Phân tử khối
44324.5000
Độ tan chảy
59 °C at pH 7.8
Độ kỵ nước
-0.302
Điểm đẳng điện tích
5.37
Dược Lực Học : Prevents excessive accumulation of active neutrophil elastase and consequent proteolysis of elastin tissues in alveolar lung structures. This prevents the development of emphysema.
Cơ Chế Tác Dụng : Human alpha-1 proteinase inhibitor or alpha-1-antitrypsin, prepared from human plasma via Cohn alcohol fractionation followed by PEG and zinc chloride fractionation. Alpha-1 proteinase inhibitor is a serine protease inhibitor (Serpin). Its primary mechanism is inhibiting the action of the serine protease called elastase (also plasmin and thrombin) in the lungs. The reactive center loop (RCL) of alpha-1 proteinase inhibitor extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site, establishing a covalent linkage between the carboxyl group of the serpin reactive site and the serine hydroxyl of the protease. The resulting inactive serpin-protease complex is highly stable.
Dược Động Học :

▧ Volume of Distribution :
* 5632 ± 2006 mL [ARALAST NP] * 5618 ± 1618 mL [Aralast]
▧ Clearance :
* 940 +/- 275 mL/day [Patients with congenital α1-PI deficiency with single IV infusion of 60 mg/kg]
Chỉ Định : For treatment of panacinar emphysema
Liều Lượng & Cách Dùng : Injection, powder, lyophilized, for solution - Intravenous
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00058
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0944-2802-01
GenBank
http://www.ncbi.nlm.nih.gov/nuccore/K01396
PharmGKB
http://www.pharmgkb.org/drug/PA10308
Wikipedia
http://en.wikipedia.org/wiki/Alpha_1-antitrypsin
RxList
http://www.rxlist.com/cgi/generic3/zemaira.htm
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