Tìm theo
Almitrine
Các tên gọi khác (3) :
  • 2,4-Bis(allylamino)-6-(4-(bis(P-fluorophenyl)methyl)-1-piperazinyl)-S-triazine
  • Almitrina
  • Almitrinum
Thuốc tác dụng trên đường hô hấp
Thuốc Gốc
Small Molecule
CAS: 27469-53-0
ATC: R07AB07
ĐG : Centocor Ortho Biotech Inc. , http://www.centocororthobiotech.com
CTHH: C26H29F2N7
PTK: 477.5522
A respiratory stimulant that enhances respiration by acting as an agonist of peripheral chemoreceptors located on the carotid bodies. The drug increases arterial oxygen tension while decreasing arterial carbon dioxide tension in patients with chronic obstructive pulmonary disease. It may also prove useful in the treatment of nocturnal oxygen desaturation without impairing the quality of sleep. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C26H29F2N7
Phân tử khối
477.5522
Monoisotopic mass
477.245250373
InChI
InChI=1S/C26H29F2N7/c1-3-13-29-24-31-25(30-14-4-2)33-26(32-24)35-17-15-34(16-18-35)23(19-5-9-21(27)10-6-19)20-7-11-22(28)12-8-20/h3-12,23H,1-2,13-18H2,(H2,29,30,31,32,33)
InChI Key
InChIKey=OBDOVFRMEYHSQB-UHFFFAOYSA-N
IUPAC Name
6-{4-[bis(4-fluorophenyl)methyl]piperazin-1-yl}-2-N,4-N-bis(prop-2-en-1-yl)-1,3,5-triazine-2,4-diamine
Traditional IUPAC Name
almitrine
SMILES
FC1=CC=C(C=C1)C(N1CCN(CC1)C1=NC(NCC=C)=NC(NCC=C)=N1)C1=CC=C(F)C=C1
Độ hòa tan
1.44e-02 g/l
logP
6.05
logS
-4.5
pKa (strongest acidic)
14.27
pKa (Strongest Basic)
7.49
PSA
69.21 Å2
Refractivity
140.88 m3·mol-1
Polarizability
51.12 Å3
Rotatable Bond Count
10
H Bond Acceptor Count
7
H Bond Donor Count
2
Physiological Charge
1
Number of Rings
4
Bioavailability
1
MDDR-Like Rule
true
Dược Lực Học : Almitrine is a respiratory stimulant that enhances respiration by acting as an agonist of peripheral chemoreceptors located on the carotid bodies. The drug increases arterial oxygen tension while decreasing arterial carbon dioxide tension in patients with chronic obstructive pulmonary disease. It may also prove useful in the treatment of nocturnal oxygen desaturation without impairing the quality of sleep.
Cơ Chế Tác Dụng : A respiratory stimulant that enhances respiration by acting as an agonist of peripheral chemoreceptors located on the carotid bodies. The drug increases arterial oxygen tension while decreasing arterial carbon dioxide tension in patients with chronic obstructive pulmonary disease. It may also prove useful in the treatment of nocturnal oxygen desaturation without impairing the quality of sleep. [PubChem] Almitrine enhances respiration by acting as an agonist of peripheral chemoreceptors located on the carotid bodies. The drug increases arterial oxygen tension while decreasing arterial carbon dioxide tension in patients with chronic obstructive pulmonary disease.
Chỉ Định : For the treatment of chronic obstructive pulmonary disease.
Dữ Kiện Thương Mại
Giá thị trường
  • Biệt dược thương mại : Doxil 2 mg/ml vial
    Giá bán buôn : USD >115.78
    Đơn vị tính : ml
Nhà Sản Xuất
  • Công ty : Servier
    Sản phẩm biệt dược : Duxil
  • Công ty :
    Sản phẩm biệt dược : Vectarion
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01430
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=33887
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46505517
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D02822
ChemSpider
http://www.chemspider.com/Chemical-Structure.31235.html
PharmGKB
http://www.pharmgkb.org/drug/PA164750492
Wikipedia
http://en.wikipedia.org/wiki/Almitrine
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