Tìm theo
Allylestrenol
Các tên gọi khác (3) :
  • Allyl estrenol
  • Allyloestrenol
  • Perselin
Hormon, Nội tiết tố
Thuốc Gốc
Small Molecule
CAS: 432-60-0
ATC: G03DC01
CTHH: C21H32O
PTK: 300.4782
A synthetic steroid with progestational activity. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C21H32O
Phân tử khối
300.4782
Monoisotopic mass
300.245315646
InChI
InChI=1S/C21H32O/c1-3-12-21(22)14-11-19-18-9-8-15-6-4-5-7-16(15)17(18)10-13-20(19,21)2/h3,6,16-19,22H,1,4-5,7-14H2,2H3/t16-,17+,18+,19-,20-,21-/m0/s1
InChI Key
InChIKey=ATXHVCQZZJYMCF-XUDSTZEESA-N
IUPAC Name
(1S,2R,10R,11S,14R,15S)-15-methyl-14-(prop-2-en-1-yl)tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-14-ol
Traditional IUPAC Name
allylestrenol
SMILES
[H][C@@]12CC[C@@](O)(CC=C)[C@@]1(C)CC[C@]1([H])[C@@]3([H])CCCC=C3CC[C@@]21[H]
Độ tan chảy
80 °C
Độ hòa tan
5.58e-04 g/l
logP
4.83
logS
-5.7
pKa (Strongest Basic)
-0.17
PSA
20.23 Å2
Refractivity
93.14 m3·mol-1
Polarizability
37.17 Å3
Rotatable Bond Count
2
H Bond Acceptor Count
1
H Bond Donor Count
1
Physiological Charge
0
Number of Rings
4
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Allylestrenol is a progestogen structurally related to progesterone that has been given in threatened and recurrent miscarriage, and to prevent premature labour. However, with the exception of proven progesterone deficiency, such use is no longer recommended. In threatened miscarriage in progesterone-deficient women a suggested dose is 5 mg three times daily by mouth for 5 to 7 days.
Cơ Chế Tác Dụng : A synthetic steroid with progestational activity. [PubChem] Allylestrenol is similar in structure and function to progesterone. Progesterone shares the pharmacological actions of the progestins. Progesterone binds to the progesterone and estrogen receptors. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Once bound to the receptor, progestins like Progesterone will slow the frequency of release of gonadotropin releasing hormone (GnRH) from the hypothalamus and blunt the pre-ovulatory LH (luteinizing hormone) surge. In women who have adequate endogenous estrogen, progesterone transforms a proliferative endometrium into a secretory one. Progesterone is essential for the development of decidual tissue and is necessary to increase endometrial receptivity for implantation of an embryo. Once an embryo has been implanted, progesterone acts to maintain the pregnancy. Progesterone also stimulates the growth of mammary alveolar tissue and relaxes uterine smooth muscle. It has little estrogenic and androgenic activity.
Dược Động Học :

▧ Route of Elimination :
The glucuronide and sulfate conjugates of pregnanediol and pregnanolone are excreted in the urine and bile. Progesterone metabolites which are excreted in the bile may undergo enterohepatic recycling or may be excreted in the feces. Progesterone metabolites are excreted mainly by the kidneys.
Chỉ Định : Allylestrenol was designed to be used for miscarriage prevention, prevention of premature labour and has been investigated for possible use in men for treatment for benign prostatic hyperplasia.
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Gestanin
  • Công ty :
    Sản phẩm biệt dược : Gestanol
  • Công ty :
    Sản phẩm biệt dược : Gestanon
  • Công ty :
    Sản phẩm biệt dược : Gestin
  • Công ty :
    Sản phẩm biệt dược : Gestrenol
  • Công ty :
    Sản phẩm biệt dược : Maintaine
  • Công ty :
    Sản phẩm biệt dược : Orageston
  • Công ty :
    Sản phẩm biệt dược : Profar
  • Công ty :
    Sản phẩm biệt dược : Turinal
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01431
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=235905
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46506946
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C12811
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D01374
ChemSpider
http://www.chemspider.com/Chemical-Structure.205855.html
PharmGKB
http://www.pharmgkb.org/drug/PA164745307
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