Tìm theo
Alizapride
Các tên gọi khác (3) :
  • Alizaprida
  • Alizapridum
  • Plitican
antiemetics, prokinetic agents
Thuốc Gốc
Small Molecule
CAS: 59338-93-1
ATC: A03FA05
CTHH: C16H21N5O2
PTK: 315.3702
Alizapride is a dopamine antagonist with prokinetic and antiemetic effects used in the treatment of nausea and vomiting, including postoperative nausea and vomiting.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C16H21N5O2
Phân tử khối
315.3702
Monoisotopic mass
315.169524941
InChI
InChI=1S/C16H21N5O2/c1-3-6-21-7-4-5-11(21)10-17-16(22)12-8-13-14(19-20-18-13)9-15(12)23-2/h3,8-9,11H,1,4-7,10H2,2H3,(H,17,22)(H,18,19,20)
InChI Key
InChIKey=KSEYRUGYKHXGFW-UHFFFAOYSA-N
IUPAC Name
6-methoxy-N-{[1-(prop-2-en-1-yl)pyrrolidin-2-yl]methyl}-2H-1,2,3-benzotriazole-5-carboxamide
Traditional IUPAC Name
6-methoxy-N-{[1-(prop-2-en-1-yl)pyrrolidin-2-yl]methyl}-2H-1,2,3-benzotriazole-5-carboxamide
SMILES
COC1=CC2=NNN=C2C=C1C(=O)NCC1CCCN1CC=C
Độ tan chảy
139 °C
Độ hòa tan
4.95e-01 g/l
logP
1.79
logS
-2.8
pKa (strongest acidic)
8.86
pKa (Strongest Basic)
7.77
PSA
83.14 Å2
Refractivity
89.21 m3·mol-1
Polarizability
33.92 Å3
Rotatable Bond Count
6
H Bond Acceptor Count
5
H Bond Donor Count
2
Physiological Charge
1
Number of Rings
3
Bioavailability
1
Rule of Five
true
Ghose Filter
true
MDDR-Like Rule
true
Dược Lực Học : Alizapride is a dopamine antagonist.
Cơ Chế Tác Dụng : Alizapride is a dopamine antagonist with prokinetic and antiemetic effects used in the treatment of nausea and vomiting, including postoperative nausea and vomiting. The anti-emetic action of Alizapride is due to its antagonist activity at D2 receptors in the chemoreceptor trigger zone (CTZ) in the central nervous system (CNS)—this action prevents nausea and vomiting triggered by most stimuli. Structurally similar to metoclopramide and, therefore, shares similar other atributres related to emesis and prokinetics.
Dược Động Học :

▧ Route of Elimination :
renal
▧ Half Life :
3 hours
Chỉ Định : Alizapride is used in the treatment of nausea and vomiting, including postoperative nausea and vomiting.
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Limican
  • Công ty : Delagrange
    Sản phẩm biệt dược : Plitican
  • Công ty : Delagrange
    Sản phẩm biệt dược : Vergentan
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01425
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=43008
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46505555
ChemSpider
http://www.chemspider.com/Chemical-Structure.39202.html
BindingDB
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50023804
PharmGKB
http://www.pharmgkb.org/drug/PA164744894
Wikipedia
http://en.wikipedia.org/wiki/Alizapride
... loading
... loading