Tìm theo
Alitretinoin
Các tên gọi khác (11 ) :
  • (2e,4e,6Z,8e)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid
  • (7e,9Z,11e,13e)-Retinoic acid
  • 9-cis-Retinoic acid
  • 9-cis-Tretinoin
  • 9(Z)-Retinoic acid
  • Alitretinoin
  • Alitretinoína
  • Alitrétinoïne
  • Alitretinoinum
  • Panretin
  • Panretyn
Thuốc điều trị ung thư
Thuốc Gốc
Small Molecule
CAS: 5300-03-8
ATC: L01XX22, D11AH04
ĐG : Basilea Pharmaceuticals Corp. , http://www.basilea.com
CTHH: C20H28O2
PTK: 300.4351
An important regulator of gene expression during growth and development, and in neoplasms. Tretinoin, also known as retinoic acid and derived from maternal vitamin A, is essential for normal growth; and embryonic development. An excess of tretinoin can be teratogenic. It is used in the treatment of psoriasis; acne vulgaris; and several other skin diseases. It has also been approved for use in promyelocytic leukemia (leukemia, promyelocytic, acute). [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C20H28O2
Phân tử khối
300.4351
Monoisotopic mass
300.20893014
InChI
InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8-,16-14+
InChI Key
InChIKey=SHGAZHPCJJPHSC-ZVCIMWCZSA-N
IUPAC Name
(2E,4E,6Z,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid
Traditional IUPAC Name
9-cis-retinoic acid
SMILES
C\C(\C=C\C1=C(C)CCCC1(C)C)=C\C=C\C(\C)=C\C(O)=O
Độ tan chảy
189-190 °C
Độ hòa tan
0.6 mg/L
logP
4.2
logS
-4.8
pKa (strongest acidic)
5
PSA
37.3 Å2
Refractivity
97.79 m3·mol-1
Polarizability
35.95 Å3
Rotatable Bond Count
5
H Bond Acceptor Count
2
H Bond Donor Count
1
Physiological Charge
-1
Number of Rings
1
Bioavailability
1
Ghose Filter
true
Dược Lực Học : Alitretinoin (9-cis-retinoic acid) is a naturally-occurring endogenous retinoid indicated for topical treatment of cutaneous lesions in patients with AIDS-related Kaposi's sarcoma. Alitretinoin inhibits the growth of Kaposi's sarcoma (KS) cells in vitro.
Cơ Chế Tác Dụng : An important regulator of gene expression during growth and development, and in neoplasms. Tretinoin, also known as retinoic acid and derived from maternal vitamin A, is essential for normal growth; and embryonic development. An excess of tretinoin can be teratogenic. It is used in the treatment of psoriasis; acne vulgaris; and several other skin diseases. It has also been approved for use in promyelocytic leukemia (leukemia, promyelocytic, acute). [PubChem] Alitretinoin binds to and activates all known intracellular retinoid receptor subtypes (RARa, RARb, RARg, RXRa, RXRb and RXRg). Once activated these receptors function as transcription factors that regulate the expression of genes that control the process of cellular differentiation and proliferation in both normal and neoplastic cells.
Chỉ Định : For topical treatment of cutaneous lesions in patients with AIDS-related Kaposi's sarcoma.
Liều Lượng & Cách Dùng : Capsule - Oral
Cream - Topical
Gel - Topical
Liquid - Topical
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty : Eisai
    Sản phẩm biệt dược : Panretin
  • Công ty : Basilea
    Sản phẩm biệt dược : Toctino
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00523
BindingDB
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31883
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/64365-501-01
PharmGKB
http://www.pharmgkb.org/drug/PA164746900
Wikipedia
http://en.wikipedia.org/wiki/Alitretinoin
RxList
http://www.rxlist.com/cgi/generic2/alitre.htm
Drugs.com
http://www.drugs.com/cdi/alitretinoin.html
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