Alemtuzumab

Thuốc Gốc

Biotech

CAS: 216503-57-0

ATC: L01XC04

ĐG : Bayer Healthcare , http://www.bayerhealthcare.com

CTHH: C₆₄₆₈H₁₀₀₆₆N₁₇₃₂O₂₀₀₅S₄₀

PTK: 145453.8000

Humanized monoclonal antibody specific to lymphocyte antigens. It is a recombinant DNA-derived humanized monoclonal antibody (Campath-1H) that is directed against the 21-28 kD cell surface glycoprotein,CD52. The Campath-1H antibody is an IgG1 kappa with human variable framework and constant regions, and complementarity-determining regions from a murine (rat) monoclonal antibody (Campath-1G). Campath is produced in mammalian cell (Chinese hamster ovary) suspension culture in a medium containing neomycin.

Nhận Dạng Quốc Tế & Đặc Tính Hóa Học

Công thức hóa học

C₆₄₆₈H₁₀₀₆₆N₁₇₃₂O₂₀₀₅S₄₀

Phân tử khối

145453.8000

Độ tan chảy

61 °C (FAB fragment), 71 °C (whole mAb)

Độ kỵ nước

-0.431

Điểm đẳng điện tích

8.76

Dược Lực Học : Campath is used to treat leukemia by exploiting antibody mediated lysis of CD52 presenting cells. The CD52 antigen is a cell surface protein found on essentially all B and T lymphocytes, a majority of monocytes, macrophages and most granulocytes. The CD52 antigen is not present on erythrocytes or hematopoetic stem cells. In leukemia there is an excess of B and T cells, so Campath permits selective reduction of lymphocyte populations.

Cơ Chế Tác Dụng : Humanized monoclonal antibody specific to lymphocyte antigens. It is a recombinant DNA-derived humanized monoclonal antibody (Campath-1H) that is directed against the 21-28 kD cell surface glycoprotein,CD52. The Campath-1H antibody is an IgG1 kappa with human variable framework and constant regions, and complementarity-determining regions from a murine (rat) monoclonal antibody (Campath-1G). Campath is produced in mammalian cell (Chinese hamster ovary) suspension culture in a medium containing neomycin. Campath binds to the CD52 antigen present on most B and T lymphocytes. This binding leads to antibody-dependent lysis of leukemic cells.

Dược Động Học :

▧ Volume of Distribution :
* 0.18 L/kg
▧ Metabolism :
Most likely removed by opsonization via the reticuloendothelial system when bound to B or T lymphocytes
▧ Half Life :
~288 hrs

Chỉ Định : Alemtuzumab (Campath) is a monoclonal antibody therapy used for treatment of B-cell chronic lymphocytic leukemia.

Tương Tác Thuốc :

Trastuzumab Trastuzumab may increase the risk of neutropenia and anemia. Monitor closely for signs and symptoms of adverse events.

Liều Lượng & Cách Dùng : Solution - Intravenous

Dữ Kiện Thương Mại

Giá thị trường

Biệt dược thương mại : Campath 30 mg/ml vial

Giá bán buôn : USD >2042.18

Đơn vị tính : ml
Biệt dược thương mại : Campath 30 mg/ml Solution (1 Box Contains Three 1ml Vials)

Giá bán buôn : USD >6179.24

Đơn vị tính : box

Nhà Sản Xuất

Công ty : ILEX Pharmaceuticals LP

Sản phẩm biệt dược : Campath
Công ty :

Sản phẩm biệt dược : MabCampath

Đóng gói

Công ty : Bayer Healthcare

Website : http://www.bayerhealthcare.com
Công ty : Boehringer Ingelheim Ltd.

Website : http://www.boehringer-ingelheim.com
Công ty : Genzyme Inc.

Website : http://www.genzyme.ca
Công ty : ILEX Pharmaceuticals LP

Tài Liệu Tham Khảo Thêm

drugbank

http://www.drugbank.ca/drugs/DB00087

National Drug Code Directory

http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/50419-357-03

PharmGKB

http://www.pharmgkb.org/drug/PA164783958

Wikipedia

http://en.wikipedia.org/wiki/Alemtuzumab

RxList

http://www.rxlist.com/cgi/generic/campath.htm

Drugs.com

http://www.drugs.com/cdi/alemtuzumab.html

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