Tìm theo
Alefacept
Các tên gọi khác (1) :
  • ASP0485
dermatologic agents, immunosuppressive agents
Thuốc Gốc
Biotech
CAS: 222535-22-0
ATC: L04AA15
ĐG : Astellas Pharma Inc. , http://www.astellas.com
CTHH: C2306H3594N610O694S26
PTK: 51801.1000
Immunosuppressive dimeric fusion protein that consists of the extracellular CD2-binding portion of the human leukocyte function antigen-3 (LFA-3) linked to the Fc (hinge, CH2 and CH3 domains) portion of human IgG1. Produced by CHO cells, mW is 91.4 kD.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C2306H3594N610O694S26
Phân tử khối
51801.1000
Độ kỵ nước
-0.432
Điểm đẳng điện tích
7.86
Dược Lực Học : Interferes with lymphocyte activation by specifically binding to the lymphocyte antigen, CD2, and inhibiting LFA-3/CD2 interaction. Activation of T lymphocytes involving the interaction between LFA-3 on antigen-presenting cells and CD2 on T lymphocytes plays a role in the pathophysiology of chronic plaque psoriasis. Also causes a reduction in subsets of CD2+ T lymphocytes as well as CD4+ and CD8+ T lymphocytes.
Cơ Chế Tác Dụng : Immunosuppressive dimeric fusion protein that consists of the extracellular CD2-binding portion of the human leukocyte function antigen-3 (LFA-3) linked to the Fc (hinge, CH2 and CH3 domains) portion of human IgG1. Produced by CHO cells, mW is 91.4 kD. Inhibits T-lymphocyte activation and production by binding to the CD2 lymphocyte antigen.
Dược Động Học :
▧ Absorption :
Bioavailability after IM administration is 63%.
▧ Half Life :
~270 hours
Độc Tính : While it has been found to cross the placenta in monkeys, it is not yet known if it also diffuses into breast milk.
Chỉ Định : As an immunosuppressive drug, Alefacept can be used for treatment of moderate to severe chronic plaque psoriasis
Tương Tác Thuốc :
  • Canakinumab Increases immunosuppressive effects and risk of infection.
  • Rilonacept results in increased immunosuppressive effects; increases the risk of infection.
Liều Lượng & Cách Dùng : Powder, for solution - Intramuscular
Dữ Kiện Thương Mại
Giá thị trường
  • Biệt dược thương mại : Amevive 15 mg vial
    Giá bán buôn : USD >1190.4
    Đơn vị tính : vial
Nhà Sản Xuất
  • Công ty : Biogen Inc.
    Sản phẩm biệt dược : Amevive
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00092
PharmGKB
http://www.pharmgkb.org/drug/PA164748040
Wikipedia
http://en.wikipedia.org/wiki/Alefacept
RxList
http://www.rxlist.com/cgi/generic3/amevive.htm
Drugs.com
http://www.drugs.com/cdi/alefacept.html
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