Tìm theo
Aldosterone
Các tên gọi khác (18 ) :
  • (+)-aldosterone
  • 11beta,21-Dihydroxy-3,20-diketo-4-pregnen-18-al
  • 11beta,21-Dihydroxy-3,20-diketopregn-4-ene-18-al
  • 11beta,21-dihydroxy-3,20-dioxo-4-pregnen-18-al
  • 11beta,21-dihydroxy-3,20-dioxo-pregn-4-ene-18-al
  • 11beta,21-dihydroxy-3,20-dioxopregn-4-en-18-al
  • 11beta,21-Dihydroxypregn-4-ene-3,18,20-trione
  • 18-Aldocorticosterone
  • 18-Formyl-11beta,21-dihydroxy-4-pregnene-3,20-dione
  • 18-Oxocorticosterone
  • Aldocorten
  • Aldocortene
  • Aldocortin
  • Aldosterona
  • Aldosteronum
  • D-aldosterone
  • Electrocortin
  • Elektrocortin
Thuốc Gốc
Small Molecule
CAS: 52-39-1
ATC: H02AA01
CTHH: C21H28O5
PTK: 360.444
A hormone secreted by the adrenal cortex that regulates electrolyte and water balance by increasing the renal retention of sodium and the excretion of potassium. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C21H28O5
Phân tử khối
360.444
Monoisotopic mass
360.193674006
InChI
InChI=1S/C21H28O5/c1-20-7-6-13(24)8-12(20)2-3-14-15-4-5-16(18(26)10-22)21(15,11-23)9-17(25)19(14)20/h8,11,14-17,19,22,25H,2-7,9-10H2,1H3/t14-,15-,16+,17-,19+,20-,21+/m0/s1
InChI Key
InChIKey=PQSUYGKTWSAVDQ-ZVIOFETBSA-N
IUPAC Name
(1S,2R,10S,11S,14S,15R,17S)-17-hydroxy-14-(2-hydroxyacetyl)-2-methyl-5-oxotetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-ene-15-carbaldehyde
Traditional IUPAC Name
aldosterone
SMILES
[H][C@@]1(CC[C@@]2([H])[C@]3([H])CCC4=CC(=O)CC[C@]4(C)[C@@]3([H])[C@@]([H])(O)C[C@]12C=O)C(=O)CO
Độ tan chảy
166.5 °C
Độ hòa tan
51.2 mg/L (at 37 °C)
logP
1.08
logS
-3.4
pKa (strongest acidic)
13.82
pKa (Strongest Basic)
-2.9
PSA
91.67 Å2
Refractivity
96.79 m3·mol-1
Polarizability
38.87 Å3
Rotatable Bond Count
3
H Bond Acceptor Count
5
H Bond Donor Count
2
Physiological Charge
0
Number of Rings
4
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : At the late distal tubule and collecting duct, aldosterone has two main actions: 1) aldosterone acts on mineralocorticoid receptors (MR) on principal cells in the distal tubule of the kidney nephron, increasing the permeability of their apical (luminal) membrane to potassium and sodium and activates their basolateral Na+/K+ pumps, stimulating ATP hydrolysis leading to phosphorylation of the pump and a conformational change in the pump exposes the Na+ ions to the outside. The phosphorylated form of the pump has a low affinity for Na+ ions, hence reabsorbing sodium (Na+) ions and water into the blood, and secreting potassium (K+) ions into the urine; 2) aldosterone stimulates H+ secretion by intercalated cells in the collecting duct, regulating plasma bicarbonate (HCO3−) levels and its acid/base balance; and 3) aldosterone may act on the central nervous system via the posterior pituitary gland to release vasopressin (ADH) which serves to conserve water by direct actions on renal tubular resorption.
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB04630
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=5839
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46505770
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C01780
ChemSpider
http://www.chemspider.com/Chemical-Structure.5633.html
PharmGKB
http://www.pharmgkb.org/drug/PA164924487
Wikipedia
http://en.wikipedia.org/wiki/Aldosterone
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