Tìm theo
Alclometasone
Các tên gọi khác (3) :
  • 7alpha-Chloro-16alpha-methylprednisolone
  • 7α-Chloro-16α-methylprednisolone
  • Aclometasone
antipruritics, corticosteroids
Thuốc Gốc
Small Molecule
CAS: 66734-13-2
ATC: D07AB10, S01BA10
ĐG : Dispensing Solutions , http://www.drxdispensing.com
CTHH: C22H29ClO5
PTK: 408.916
Alclometasone is synthetic glucocorticoid steroid for topical use in dermatology as anti-inflammatory, antipruritic, antiallergic, antiproliferative and vasoconstrictive agent. [Wikipedia]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C22H29ClO5
Phân tử khối
408.916
Monoisotopic mass
408.170351745
InChI
InChI=1S/C22H29ClO5/c1-11-6-14-18-15(23)8-12-7-13(25)4-5-20(12,2)19(18)16(26)9-21(14,3)22(11,28)17(27)10-24/h4-5,7,11,14-16,18-19,24,26,28H,6,8-10H2,1-3H3/t11-,14+,15-,16+,18-,19+,20+,21+,22+/m1/s1
InChI Key
InChIKey=FJXOGVLKCZQRDN-PHCHRAKRSA-N
IUPAC Name
(1S,2R,9R,10S,11S,13R,14R,15S,17S)-9-chloro-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,13,15-trimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-dien-5-one
Traditional IUPAC Name
alclometasone
SMILES
[H][C@@]12C[C@@H](C)[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1([H])[C@@]2([H])[C@H](Cl)CC2=CC(=O)C=C[C@]12C
Độ hòa tan
Insoluble
logP
2.7
logS
-3.5
pKa (strongest acidic)
12.45
pKa (Strongest Basic)
-2.9
PSA
94.83 Å2
Refractivity
107.61 m3·mol-1
Polarizability
42.62 Å3
Rotatable Bond Count
2
H Bond Acceptor Count
5
H Bond Donor Count
3
Physiological Charge
0
Number of Rings
4
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Alclometasone is a synthetic corticosteroid for topical dermatologic use. The corticosteroids constitute a class of primarily synthetic steroids used topically as anti-inflammatory and antipruritic agents. Alclometasone is a selective glucocorticoid receptor agonist.
Cơ Chế Tác Dụng : Alclometasone is synthetic glucocorticoid steroid for topical use in dermatology as anti-inflammatory, antipruritic, antiallergic, antiproliferative and vasoconstrictive agent. [Wikipedia] The mechanism of the anti-inflammatory activity of the topical steroids, in general, is unclear. However, corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor, arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2. Alclometasone initially binds the corticosteroid receptor. This complex migrates to the nucleus where it binds to different glucocorticoid response elements on the DNA. This in turn enhances and represses various genes, especially those involved in inflammatory pathways.
Dược Động Học :
▧ Absorption :
Topical corticosteroids can be absorbed from normal intact skin. Studies have shown that approximately 3% of steroid is absorbed during 8 hours of contact with intact skin of normal volunteers.
▧ Metabolism :
Hepatic.
Độc Tính : Symptoms of overdose include suppression of adrenal glands, temporary decrease in white blood cell counts, symptoms of hypersensitivity (such as skin rash, hives, itching, and difficulty breathing), and increased susceptibility to infection.
Chỉ Định : For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.
Liều Lượng & Cách Dùng : Cream - Topical
Ointment - Topical
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Aclovate
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00240
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D01820
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/68462-300-17
PharmGKB
http://www.pharmgkb.org/drug/PA164747650
Wikipedia
http://en.wikipedia.org/wiki/Alclometasone
RxList
http://www.rxlist.com/cgi/generic3/alclometasone.htm
PDRhealth
http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/acl1005.shtml
Drugs.com
http://www.drugs.com/cdi/alclometasone-cream.html
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