Tìm theo
AL-108
Thuốc Gốc
Biotech
AL-108 is the first drug to improve memory performance by impacting the mechanisms that lead to physical damage in the brain caused by neurofibrillary tangles, one of the two established pathological hallmarks that are common to amnestic mild cognitive impairment (aMCI) and Alzheimer's disease (AD). AL-108 is derived from a naturally occurring neuroprotective brain protein known as activity dependent neuroprotective protein.
Cơ Chế Tác Dụng : AL-108 is the first drug to improve memory performance by impacting the mechanisms that lead to physical damage in the brain caused by neurofibrillary tangles, one of the two established pathological hallmarks that are common to amnestic mild cognitive impairment (aMCI) and Alzheimer's disease (AD). AL-108 is derived from a naturally occurring neuroprotective brain protein known as activity dependent neuroprotective protein. AL-108 interacts with microtubules 1) preventing the formation of neurofibrillary tanges and protecting the network from a 'death signal' or 2) repairing the network if the brain cell death process has already begun. The restoration of the microtubule network explains the results shown in treated animals which have improved cognitive performance compared to untreated groups.
Chỉ Định : Investigated for use/treatment in alzheimer's disease and neurologic disorders.
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB05907
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