Tìm theo
Afimoxifene
Các tên gọi khác (3) :
  • 4-Hydroxytamoxifen
  • 4-OHT
  • hydroxytamoxife
estrogen antagonists
Thuốc Gốc
Small Molecule
CAS: 65213-48-1
CTHH: C26H29NO2
PTK: 387.514
Afimoxifene (4-Hydroxytamoxifen, trade name TamoGel) is a new estrogen inhibitor under investigation for a variety of estrogen-dependent conditions, including cyclic breast pain and gynecomastia. TamoGel is formulated using Enhanced Hydroalcoholic Gel (EHG) Technology. This technology enables percutaneous delivery of drugs that cannot be delivered orally. It is being developed by Ascent Therapeutics.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C26H29NO2
Phân tử khối
387.514
Monoisotopic mass
387.219829177
InChI
InChI=1S/C26H29NO2/c1-4-25(20-8-6-5-7-9-20)26(21-10-14-23(28)15-11-21)22-12-16-24(17-13-22)29-19-18-27(2)3/h5-17,28H,4,18-19H2,1-3H3/b26-25+
InChI Key
InChIKey=TXUZVZSFRXZGTL-OCEACIFDSA-N
IUPAC Name
4-[(1E)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-2-phenylbut-1-en-1-yl]phenol
Traditional IUPAC Name
4-[(1E)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-2-phenylbut-1-en-1-yl]phenol
SMILES
CC\C(=C(\C1=CC=C(O)C=C1)C1=CC=C(OCCN(C)C)C=C1)C1=CC=CC=C1
Độ hòa tan
3.03e-03 g/l
logP
5.69
logS
-5.1
pKa (strongest acidic)
9.45
pKa (Strongest Basic)
8.66
PSA
32.7 Å2
Refractivity
130.41 m3·mol-1
Polarizability
45.44 Å3
Rotatable Bond Count
8
H Bond Acceptor Count
3
H Bond Donor Count
1
Physiological Charge
1
Number of Rings
3
Bioavailability
1
MDDR-Like Rule
true
Cơ Chế Tác Dụng : Afimoxifene (4-Hydroxytamoxifen, trade name TamoGel) is a new estrogen inhibitor under investigation for a variety of estrogen-dependent conditions, including cyclic breast pain and gynecomastia. TamoGel is formulated using Enhanced Hydroalcoholic Gel (EHG) Technology. This technology enables percutaneous delivery of drugs that cannot be delivered orally. It is being developed by Ascent Therapeutics. Afimoxifene binds to estrogen receptors (ER), inducing a conformational change in the receptor. This results in a blockage or change in the expression of estrogen dependent genes.
Dược Động Học :
▧ Absorption :
Absorbed following topical application.
Chỉ Định : For the potential treatment of menstrual-cycle related mastalgia, fibrocystic breast disease, breast disease, gynecomastia and Keloid scarring.
Liều Lượng & Cách Dùng : Gel - Topical
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Tamogel
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB04468
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=449459
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=7889566
ChemSpider
http://www.chemspider.com/Chemical-Structure.4509087.html
BindingDB
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=20608
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