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Adenosine monophosphate
Các tên gọi khác (22 ) :
  • 5'-Adenosine monophosphate
  • 5'-Adenylic acid
  • 5'-AMP
  • 5'-O-Phosphonoadenosine
  • Adenosine 5'-(dihydrogen phosphate)
  • Adenosine 5'-monophosphate
  • Adenosine 5'-phosphate
  • ADENOSINE monophosphate
  • Adenosine phosphate
  • Adenosine-5'-Monophosphate
  • Adenosine-5'-monophosphoric acid
  • Adenosine-5'p
  • Adenosini phosphas
  • Adenylate
  • Adenylic acid
  • Ado5'p
  • AMP
  • Fosfato de adenosina
  • PAdo
  • Phosaden
  • Phosphaden
  • Phosphate d'adenosine
dietary supplements, micronutrients, supplements
Thuốc Gốc
Small Molecule
CAS: 61-19-8
ĐG : Spectrum Pharmaceuticals , http://www.spectrumpharm.com
CTHH: C10H14N5O7P
PTK: 347.2212
Adenylic acid. Adenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
Phân tử khối
347.2212
Monoisotopic mass
347.063084339
InChI
InChI=1S/C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
InChI Key
InChIKey=UDMBCSSLTHHNCD-KQYNXXCUSA-N
IUPAC Name
{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid
Traditional IUPAC Name
[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxyphosphonic acid
SMILES
NC1=C2N=CN([[email protected]@H]3O[[email protected]](COP(O)(O)=O)[[email protected]@H](O)[[email protected]]3O)C2=NC=N1
Độ tan chảy
195 dec °C
Độ hòa tan
1E+004 mg/L (at 20 °C)
logP
-3.1
logS
-2
pKa (strongest acidic)
1.23
pKa (Strongest Basic)
4.97
PSA
186.07 Å2
Refractivity
74.07 m3·mol-1
Polarizability
30 Å3
Rotatable Bond Count
4
H Bond Acceptor Count
10
H Bond Donor Count
5
Physiological Charge
-2
Number of Rings
3
Bioavailability
1
Rule of Five
true
Dược Lực Học : Adenosine monophosphate, also known as 5'-adenylic acid and abbreviated AMP, is a nucleotide that is found in RNA. It is an ester of phosphoric acid with the nucleoside adenosine. AMP consists of the phosphate group, the pentose sugar ribose, and the nucleobase adenine. AMP is used as a dietary supplement to boost immune activity, and is also used as a substitute sweetener to aid in the maintenance of a low-calorie diet.
Cơ Chế Tác Dụng : Adenylic acid. Adenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position. [PubChem] Nucleotides such as Adenosine-5'-Monophosphate affect a number of immune functions, including the reversal of malnutrition and starvation-induced immunosuppression, the enhancement of T-cell maturation and function, the enhancement of natural killer cell activity, the improvement of delayed cutaneous hypersensitivity, helping resistance to such infectious agents as Staphylococcus aureus and Candida albicans, and finally the modulation of T-cell responses toward type 1 CD4 helper lymphocytes or Th1 cells. Studies have shown that mice fed a nucleotide-free diet have both impaired humoral and cellular immune responses. The addition of dietary nucleotides normalizes both types of responses. RNA, a delivery form of nucleotides, and ribonucleotides were used in these studies. The mechanism of the immune-enhancing activity of nucleic acids/nucleotides is not clear.
Chỉ Định : For nutritional supplementation, also for treating dietary shortage or imbalance
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