Tìm theo
Adenine
Các tên gọi khác (6 ) :
  • 6-Aminopurine
  • A
  • Ade
  • Adenin
  • ADENINE
  • Vitamin B4
dietary supplements, micronutrients, supplements
Thuốc Gốc
Small Molecule
CAS: 73-24-5
CTHH: C5H5N5
PTK: 135.1267
A purine base and a fundamental unit of adenine nucleotides. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C5H5N5
Phân tử khối
135.1267
Monoisotopic mass
135.054495185
InChI
InChI=1S/C5H5N5/c6-4-3-5(9-1-7-3)10-2-8-4/h1-2H,(H3,6,7,8,9,10)
InChI Key
InChIKey=GFFGJBXGBJISGV-UHFFFAOYSA-N
IUPAC Name
7H-purin-6-amine
Traditional IUPAC Name
adenine
SMILES
NC1=C2NC=NC2=NC=N1
Độ tan chảy
360 dec °C
Độ hòa tan
1030 mg/L (at 25 °C)
logP
-0.09
logS
-2.12
pKa (strongest acidic)
10.29
pKa (Strongest Basic)
5.32
PSA
80.48 Å2
Refractivity
38.22 m3·mol-1
Polarizability
12.29 Å3
Rotatable Bond Count
0
H Bond Acceptor Count
4
H Bond Donor Count
2
Physiological Charge
0
Number of Rings
2
Bioavailability
1
Rule of Five
true
pKa
4.15 (at 25 °C)
Dược Lực Học : Adenine (sometimes known as vitamin B4) combines with the sugar ribose to form adenosine, which in turn can be bonded with from one to three phosphoric acid units, yielding AMP, ADP and ATP . These adenine derivatives perform important functions in cellular metabolism. Adenine is one of four nitrogenous bases utilized in the synthesis of nucleic acids. A modified form of adenosine monophosphate (cyclic AMP) is an imporant secondary messenger in the propagation of many hormonal stimuli. Adenine is an integral part of the structure of many coenzymes. Adenosine (adenine with a ribose group) causes transient heart block in the AV node of the heart. In individuals suspected of suffering from a supraventricular tachycardia (SVT), adenosine is used to help identify the rhythm. Certain SVTs can be successfully terminated with adenosine.
Cơ Chế Tác Dụng : A purine base and a fundamental unit of adenine nucleotides. [PubChem] Adenine forms adenosine, a nucleoside, when attached to ribose, and deoxyadenosine when attached to deoxyribose, and it forms adenosine triphosphate (ATP), a nucleotide, when three phosphate groups are added to adenosine. Adenosine triphosphate is used in cellular metabolism as one of the basic methods of transferring chemical energy between reactions. In older literature, adenine was sometimes called Vitamin B4Not Available
Chỉ Định : For nutritional supplementation, also for treating dietary shortage or imbalance
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Leuco-4
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00173
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=190
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46507319
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C00147
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00034
ChemSpider
http://www.chemspider.com/Chemical-Structure.185.html
BindingDB
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=33218
PharmGKB
http://www.pharmgkb.org/drug/PA448048
Wikipedia
http://en.wikipedia.org/wiki/Adenine
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