Adalimumab

Các tên gọi khác (1) :

Ig gamma-1 chain C region

antirheumatic agents, anti inflammatory agents, immunosuppressive agents

Thuốc Gốc

Biotech

CAS: 331731-18-1

ATC: L04AB04

ĐG : Abbott Laboratories Ltd. , http://www.abbott.com

CTHH: C₆₄₂₈H₉₉₁₂N₁₆₉₄O₁₉₈₇S₄₆

PTK: 144190.3000

Adalimumab is a human monoclonal antibody against TNF-alpha. It is produced by recombinant DNA technology using a mammalian cell expression system. It consists of 1330 amino acids and has a molecular weight of approximately 148 kilodaltons.

Nhận Dạng Quốc Tế & Đặc Tính Hóa Học

Công thức hóa học

C₆₄₂₈H₉₉₁₂N₁₆₉₄O₁₉₈₇S₄₆

Phân tử khối

144190.3000

Độ kỵ nước

-0.441

Điểm đẳng điện tích

8.25

Dược Lực Học : Used in the treatment of immune system mediated diseases, adalimumab binds specifically to TNF-alpha and blocks its general cytokine effects, thereby reducing TNF-induced inflammation and halting tissue destruction.

Cơ Chế Tác Dụng : Adalimumab is a human monoclonal antibody against TNF-alpha. It is produced by recombinant DNA technology using a mammalian cell expression system. It consists of 1330 amino acids and has a molecular weight of approximately 148 kilodaltons. Adalimumab binds to TNF-alpha and blocks its interaction with the p55 and p75 cell surface TNF receptors. Adalimumab also lyses surface TNF expressing cells in vitro in the presence of complement.

Dược Động Học :

▧ Metabolism :
Most likely removed by opsonization via the reticuloendothelial system.
▧ Half Life :
10-20 days.
▧ Clearance :
* 12 mL/hr [RA patients with dose 0.25-10 mg/kg]

Chỉ Định : For treatment of rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and Crohn's disease.

Tương Tác Thuốc :

Canakinumab Increases immunosuppressive effects and risk of infection.
Infliximab Both bind to TNF alfa and thus combination results in enhanced immunosuppressive effect. It is recommended that simultaneous use of both agents be avoided.
Rilonacept results in increased immunosuppressive effects; increases the risk of infection.
Tofacitinib Adalimumab (and other anti-TNF immunosuppressants), when used in combination with tofacitinib, may increase the risk of added immunosuppression. It is recommended to avoid concurrent therapy.
Trastuzumab Trastuzumab may increase the risk of neutropenia and anemia. Monitor closely for signs and symptoms of adverse events.

Liều Lượng & Cách Dùng : Solution - Subcutaneous

Dữ Kiện Thương Mại

Giá thị trường

Biệt dược thương mại : Humira 20 mg/0.4 ml syringe

Giá bán buôn : USD >959.19

Đơn vị tính : syringe
Biệt dược thương mại : Humira 40 mg/0.8 ml pen

Giá bán buôn : USD >959.19

Đơn vị tính : pen
Biệt dược thương mại : Humira crohn's starter pack

Giá bán buôn : USD >959.19

Đơn vị tính : each
Biệt dược thương mại : Humira psoriasis starter pack

Giá bán buôn : USD >959.19

Đơn vị tính : each
Biệt dược thương mại : Humira (1 Box = Two 40 mg/0.8ml Syringes) Box

Giá bán buôn : USD >1995.1

Đơn vị tính : box
Biệt dược thương mại : Humira 2 20 mg/0.4ml Kit 1 Box = Two 20 mg/0.4ml Syringes

Giá bán buôn : USD >1995.1

Đơn vị tính : box
Biệt dược thương mại : Humira Pen 2 40 mg/0.8ml Kit (1 Box = 1 Kit Containing Two 40 mg/0.8ml Pens)

Giá bán buôn : USD >1995.1

Đơn vị tính : box

Nhà Sản Xuất

Công ty : Abbott Laboratories

Sản phẩm biệt dược : Humira
Công ty : Abbott Laboratories

Sản phẩm biệt dược : Humira Pen

Đóng gói

Công ty : Abbott Laboratories Ltd.

Website : http://www.abbott.com
Công ty : Vetter Pharma Fertigung GmbH and Co. KG

Website : http://www.vetter-pharma.com

Tài Liệu Tham Khảo Thêm

drugbank

http://www.drugbank.ca/drugs/DB00051

National Drug Code Directory

http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0074-3799-02

GenBank

http://www.ncbi.nlm.nih.gov/nuccore/J00228

PharmGKB

http://www.pharmgkb.org/drug/PA10004

Wikipedia

http://en.wikipedia.org/wiki/Adalimumab

RxList

http://www.rxlist.com/cgi/generic3/humira.htm

Drugs.com

http://www.drugs.com/cdi/adalimumab.html

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