Tìm theo
Acetohydroxamic Acid
Các tên gọi khác (18 ) :
  • Acethydroxamsaeure
  • Acethydroxamsaure
  • Acetic acid, oxime
  • Acetohydroxamate
  • Acetohydroxamic acid
  • Acetohydroximic acid
  • Acetyl hydroxyamino
  • Acetylhydroxamic acid
  • Acide acetohydroxamique
  • Acido acetohidroxamico
  • Acidum acetohydroxamicum
  • AHA
  • Cetohyroxamic acid
  • Lithostat
  • Methylhydroxamic acid
  • N-Acetyl hydroxyacetamide
  • N-Acetylhydroxylamine
  • N-Hydroxyacetamide
enzyme inhibitors
Thuốc Gốc
Small Molecule
CAS: 546-88-3
ATC: G04BX03
ĐG : Mission Pharmacal , http://www.missionpharmacal.com
CTHH: C2H5NO2
PTK: 75.0666
Acetohydroxamic Acid, a synthetic drug derived from hydroxylamine and ethyl acetate, is similar in structure to urea. In the urine, it acts as an antagonist of the bacterial enzyme urease. Acetohydroxamic Acid has no direct antimicrobial action and does not acidify urine directly. It is used, in addition to antibiotics or medical procedures, to treat chronic urea-splitting urinary infections.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C2H5NO2
Phân tử khối
75.0666
Monoisotopic mass
75.032028409
InChI
InChI=1S/C2H5NO2/c1-2(4)3-5/h5H,1H3,(H,3,4)
InChI Key
InChIKey=RRUDCFGSUDOHDG-UHFFFAOYSA-N
IUPAC Name
N-hydroxyacetamide
Traditional IUPAC Name
acetohydroxamic acid
SMILES
CC(=O)NO
Độ tan chảy
90.5 °C
Độ hòa tan
1E+006 mg/L
logP
-1.59
logS
0.83
pKa (strongest acidic)
8.94
pKa (Strongest Basic)
-5.4
PSA
49.33 Å2
Refractivity
16.23 m3·mol-1
Polarizability
6.6 Å3
Rotatable Bond Count
0
H Bond Acceptor Count
2
H Bond Donor Count
2
Physiological Charge
0
Number of Rings
0
Bioavailability
1
Rule of Five
true
pKa
8.7 (at 25 °C)
Dược Lực Học : Acetohydroxamic Acid, a synthetic drug derived from hydroxylamine and ethyl acetate, is similar in structure to urea. In the urine, it acts as an antagonist of the bacterial enzyme urease. Acetohydroxamic Acid has no direct antimicrobial action and does not acidify urine directly.
Cơ Chế Tác Dụng : Acetohydroxamic Acid, a synthetic drug derived from hydroxylamine and ethyl acetate, is similar in structure to urea. In the urine, it acts as an antagonist of the bacterial enzyme urease. Acetohydroxamic Acid has no direct antimicrobial action and does not acidify urine directly. It is used, in addition to antibiotics or medical procedures, to treat chronic urea-splitting urinary infections. Acetohydroxamic Acid reversibly inhibits the bacterial enzyme urease. This inhibits the hydrolysis of urea and production of ammonia in urine infected with urea-splitting organisms, leading to a decrease in pH and ammonia levels. As antimicrobial agents are more effective in such conditions, the effectiveness of these agents is amplified, resulting in a higher cure rate.
Dược Động Học :
▧ Absorption :
Well absorbed from the GI tract following oral administration.
▧ Protein binding :
No known binding
▧ Metabolism :
35-65% of oral dose excreted unchanged in urine (which provides the drug's therapeutic effect).
▧ Half Life :
5-10 hours in patients with normal renal function
Độc Tính : Oral, rat: LD50 = 4.8gm/kg. Symptoms of overdose include anorexia, malaise, lethargy, diminished sense of wellbeing, tremor, anxiety, nausea, and vomiting.
Chỉ Định : Used, in addition to antibiotics or medical procedures, to treat chronic urea-splitting urinary infections.
Liều Lượng & Cách Dùng : Tablet - Oral
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Lithostat
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00551
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=1990
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46508546
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C06808
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00220
ChemSpider
http://www.chemspider.com/Chemical-Structure.1913.html
PharmGKB
http://www.pharmgkb.org/drug/PA164749213
Wikipedia
http://en.wikipedia.org/wiki/Acetohydroxamic_acid
Drugs.com
http://www.drugs.com/cdi/acetohydroxamic-acid.html
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