Tìm theo
Aceprometazine
Các tên gọi khác (4 ) :
  • 10-(2-(Dimethylamino)propyl)phenothiazin-2-yl methyl ketone
  • Aceprometazina
  • Aceprometazinum
  • Acepromethazine
Thuốc an thần
Thuốc Gốc
Small Molecule
CAS: 13461-01-3
CTHH: C19H22N2OS
PTK: 326.456
Aceprometazine (INN) is a prescription drug with neuroleptic and anti-histamine properties. It is not widely prescribed. It may be used in combination with meprobamate for the treatment of sleep disorders. This combination is available in France under the trade name Mepronizine. [Wikipedia]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C19H22N2OS
Phân tử khối
326.456
Monoisotopic mass
326.145284026
InChI
InChI=1S/C19H22N2OS/c1-13(20(3)4)12-21-16-7-5-6-8-18(16)23-19-10-9-15(14(2)22)11-17(19)21/h5-11,13H,12H2,1-4H3
InChI Key
InChIKey=XLOQNFNTQIRSOX-UHFFFAOYSA-N
IUPAC Name
1-{10-[2-(dimethylamino)propyl]-10H-phenothiazin-2-yl}ethan-1-one
Traditional IUPAC Name
aceprometazine
SMILES
CC(CN1C2=CC=CC=C2SC2=C1C=C(C=C2)C(C)=O)N(C)C
Độ hòa tan
1.22e-02 g/l
logP
3.85
logS
-4.4
pKa (strongest acidic)
16.06
pKa (Strongest Basic)
8.32
PSA
23.55 Å2
Refractivity
98.91 m3·mol-1
Polarizability
36.79 Å3
Rotatable Bond Count
4
H Bond Acceptor Count
3
H Bond Donor Count
0
Physiological Charge
1
Number of Rings
3
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Aceprometazine is a drug with neuroleptic and anti-histamine properties. It is not widely prescribed.
Cơ Chế Tác Dụng : Aceprometazine (INN) is a prescription drug with neuroleptic and anti-histamine properties. It is not widely prescribed. It may be used in combination with meprobamate for the treatment of sleep disorders. This combination is available in France under the trade name Mepronizine. [Wikipedia] Aceprometazine, acting as an H1-receptor antagonist can induce sedation by being able to cross the blood-brain-barrier and binding to H1-receptors in the central nervous system.
Dược Động Học :
▧ Absorption :
Rapidly absorbed following oral administration.
▧ Metabolism :
Hepatic.
Chỉ Định : Aceprometazine is often used in combination with meprobamate for the treatment of sleep disorders.
Tương Tác Thuốc :
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Mepronizine
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01615
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=26035
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46506646
ChemSpider
http://www.chemspider.com/Chemical-Structure.24249.html
PharmGKB
http://www.pharmgkb.org/drug/PA164743727
Wikipedia
http://en.wikipedia.org/wiki/Aceprometazine
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