Tìm theo
Acepromazine
Các tên gọi khác (6 ) :
  • 1-[10-(3-DIMETHYLAMINO-propyl)-10H-phenothiazin-2-yl]-ethanone
  • 10-(3-dimethylaminopropyl)phenothiazin-3-yl methyl ketone
  • 10-(3-dimethylaminopropyl)phenothiazine-3-ethylone
  • Acetazine
  • Acetopromazine
  • Acetylpromazine
Thuốc an thần
Thuốc Gốc
Small Molecule
CAS: 61-00-7
CTHH: C19H22N2OS
PTK: 326.456
Acepromazine is one of the phenothiazine derivative psychotropic drugs, used little in humans, however frequently in animals as a sedative and antiemetic.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C19H22N2OS
Phân tử khối
326.456
Monoisotopic mass
326.145284026
InChI
InChI=1S/C19H22N2OS/c1-14(22)15-9-10-19-17(13-15)21(12-6-11-20(2)3)16-7-4-5-8-18(16)23-19/h4-5,7-10,13H,6,11-12H2,1-3H3
InChI Key
InChIKey=NOSIYYJFMPDDSA-UHFFFAOYSA-N
IUPAC Name
1-{10-[3-(dimethylamino)propyl]-10H-phenothiazin-2-yl}ethan-1-one
Traditional IUPAC Name
acepromazine
SMILES
CN(C)CCCN1C2=CC=CC=C2SC2=C1C=C(C=C2)C(C)=O
Độ tan chảy
< 25 °C
Độ sôi
230 °C at 5.00E-01 mm Hg
Độ hòa tan
9.80e-03 g/l
logP
3.49
logS
-4.5
pKa (strongest acidic)
16.06
pKa (Strongest Basic)
8.5
PSA
23.55 Å2
Refractivity
99.35 m3·mol-1
Polarizability
37.17 Å3
Rotatable Bond Count
5
H Bond Acceptor Count
3
H Bond Donor Count
0
Physiological Charge
1
Number of Rings
3
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Acepromazine is one of the phenothiazine derivative psychotropic drugs. Acepromazine has actions at all levels of the central nervous system-primarily at subcortical levels-as well as on multiple organ systems. Acepromazine has strong antiadrenergic and weaker peripheral anticholinergic activity; ganglionic blocking action is relatively slight. It also possesses slight antihistaminic and antiserotonin activity.
Cơ Chế Tác Dụng : Acepromazine is one of the phenothiazine derivative psychotropic drugs, used little in humans, however frequently in animals as a sedative and antiemetic. Acepromazine acts as an antagonist (blocking agent) on different postsysnaptic receptors -on dopaminergic-receptors (subtypes D1, D2, D3 and D4 - different antipsychotic properties on productive and unproductive symptoms), on serotonergic-receptors (5-HT1 and 5-HT2, with anxiolytic, antidepressive and antiaggressive properties as well as an attenuation of extrapypramidal side-effects, but also leading to weight gain, fall in blood pressure, sedation and ejaculation difficulties), on histaminergic-receptors (H1-receptors, sedation, antiemesis, vertigo, fall in blood pressure and weight gain), alpha1/alpha2-receptors (antisympathomimetic properties, lowering of blood pressure, reflex tachycardia, vertigo, sedation, hypersalivation and incontinence as well as sexual dysfunction, but may also attenuate pseudoparkinsonism - controversial) and finally on muscarinic (cholinergic) M1/M2-receptors (causing anticholinergic symptoms like dry mouth, blurred vision, obstipation, difficulty/inability to urinate, sinus tachycardia, ECG-changes and loss of memory, but the anticholinergic action may attenuate extrapyramidal side-effects).
Dược Động Học :

▧ Half Life :
3 hours in horses.
Độc Tính : Agitation, coma, convulsions, difficulty breathing, difficulty swallowing, dry mouth, extreme sleepiness, fever, intestinal blockage, irregular heart rate, low blood pressure, restlessness
Chỉ Định : Acepromazine was first used in humans in the 1950s as an antipsychotic agent. It is now rarely used in humans. Acepromazine is frequently used in animals as a sedative and antiemetic. Its principal value is in quietening and calming anxious animals.
Tương Tác Thuốc :
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Acezine 2
  • Công ty :
    Sản phẩm biệt dược : Atravet
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01614
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=6077
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46508205
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D02604
ChemSpider
http://www.chemspider.com/Chemical-Structure.5852.html
PharmGKB
http://www.pharmgkb.org/drug/PA164783999
Wikipedia
http://en.wikipedia.org/wiki/Acepromazine
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